Oncostatin M Secreted by Skin Infiltrating T Lymphocytes Is a Potent Keratinocyte Activator Involved in Skin Inflammation
| Autor: | Emilie Venereau, François Bernard, Laurence Preisser, Gérard Guillet, Emmanuel Guignouard, Elisa Ravon, Jérôme Pène, Caroline Diveu, Martine Garcia, Franck Morel, Jean-Claude Lecron, G. Dagregorio, Sylvie Chevalier, Josy Froger, Katia Boniface, Hugues Gascan, Jean-Pierre Molès, Nathalie Pedretti, Hans Yssel |
|---|---|
| Přispěvatelé: | Laboratoire Inflammation, Tissus épithéliaux et Cytokines (LITEC), Université de Poitiers, Cytokines : structure, signalisation et prolifération tumorale, Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM), BIOalternatives (BIOalternatives SAS), entreprise privé, Centre hospitalier universitaire de Poitiers (CHU Poitiers), Immunopathologie de l'Inflammation, Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM), Morel, Franck |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
S100A7
Keratinocytes STAT3 Transcription Factor medicine.medical_treatment T-Lymphocytes Immunology Inflammation Dermatitis Oncostatin M [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Cell Movement medicine Immunology and Allergy Humans Keratinocyte migration [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biochemistry [q-bio.BM] [SDV.IMM.II] Life Sciences [q-bio]/Immunology/Innate immunity [SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry Molecular Biology/Biochemistry [q-bio.BM] Cells Cultured ComputingMilieux_MISCELLANEOUS 030304 developmental biology Oligonucleotide Array Sequence Analysis Skin Mitogen-Activated Protein Kinase Kinases 0303 health sciences biology fungi [SDV.MHEP.DERM] Life Sciences [q-bio]/Human health and pathology/Dermatology Glycoprotein 130 Immunity Innate medicine.anatomical_structure Cytokine Gene Expression Regulation [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology 030220 oncology & carcinogenesis [SDV.IMM.IA] Life Sciences [q-bio]/Immunology/Adaptive immunology biology.protein medicine.symptom Keratinocyte Receptors Oncostatin M Type II [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology |
| Zdroj: | Journal of Immunology Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2007, 178 (7), pp.4615-4622. ⟨10.4049/jimmunol.178.7.4615⟩ Scopus-Elsevier |
| ISSN: | 0022-1767 1550-6606 |
| DOI: | 10.4049/jimmunol.178.7.4615⟩ |
| Popis: | Cutaneous inflammatory diseases such as psoriasis vulgaris and atopic dermatitis are associated with altered keratinocyte function, as well as with a particular cytokine production profile of skin-infiltrating T lymphocytes. In this study we show that normal human epidermal keratinocytes express a functional type II oncostatin-M (OSM) receptor (OSMR) consisting of the gp130 and OSMRβ components, but not the type I OSMR. The type II OSMR is expressed in skin lesions from both psoriatic patients and those with atopic dermatitis. Its ligand, OSM, induces via the recruitment of the STAT3 and MAP kinase pathways a gene expression profile in primary keratinocytes and in a reconstituted epidermis that is characteristic of proinflammatory and innate immune responses. Moreover, OSM is a potent stimulator of keratinocyte migration in vitro and increases the thickness of a reconstituted epidermis. OSM transcripts are enhanced in both psoriatic and atopic dermatitic skin as compared with healthy skin and mirror the enhanced production of OSM by T cells isolated from diseased lesions. Results from a microarray analysis comparing the gene-modulating effects of OSM with those of 33 different cytokines indicate that OSM is a potent keratinocyte activator similar to TNF-α, IL-1, IL-17, and IL-22 and that it acts in synergy with the latter cytokines in the induction of S100A7 and β-defensin 2 expression, characteristic of psoriatic skin. Taken together, these results demonstrate that OSM and its receptor play an important role in cutaneous inflammatory responses in general and that the specific effects of OSM are associated with distinct inflammatory diseases depending on the cytokine environment. |
| Databáze: | OpenAIRE |
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