Prognostic value of differentiation status in gastric cancer

Autor: Guanghui Xu, Fei Wang, Man Guo, Gaozan Zheng, Fan Feng, Shushang Liu, Jinqiang Liu, Hongwei Zhang, Xiao Lian, Qiao Wang
Rok vydání: 2018
Předmět:
Adult
Male
Oncology
Cancer Research
medicine.medical_specialty
lcsh:RC254-282
Clinicopathological characteristics
03 medical and health sciences
0302 clinical medicine
Gastrectomy
Predictive Value of Tests
Risk Factors
Stomach Neoplasms
Surgical oncology
Internal medicine
Tumor stage
Genetics
medicine
Humans
Lymph node
Male gender
Aged
Neoplasm Staging
Aged
80 and over
Sex Characteristics
Signet ring cell
business.industry
Significant difference
Cancer
Cell Differentiation
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Prognosis
medicine.disease
Adenocarcinoma
Mucinous
Well differentiated
medicine.anatomical_structure
Lymphatic Metastasis
030220 oncology & carcinogenesis
Lymph Node Excision
Female
030211 gastroenterology & hepatology
Differentiation status
Gastric cancer
business
Research Article
Zdroj: BMC Cancer
BMC Cancer, Vol 18, Iss 1, Pp 1-6 (2018)
ISSN: 1471-2407
DOI: 10.1186/s12885-018-4780-0
Popis: Background Up to date, investigation of the prognostic value of differentiation status mainly focused on signet ring cell and mucinous gastric cancer. Thus, the present study aims to investigate the clinicopathological features and prognosis of gastric cancer patients with well, moderately and poorly differentiation status. Methods From September 2008 to March 2015, a total of 3090 gastric cancer patients treated with radical D2 gastrectomy were enrolled in the present study. Clinicopathological characteristics and prognosis of gastric cancer patients with well, moderately and poorly differentiation status were analyzed. Results There were 2422 male (78.4%) and 668 female (21.6%). The median age was 58 (20–90) years. There were 370 (12.0%) well differentiated tumors, 836 (27.0%) moderately differentiated tumors and 1884 (61.0%) poorly differentiated tumors. Well and moderately differentiation status were associated with older age, male gender, smaller tumor, shallower invasion, less lymph node involvement and earlier tumor stage (all p
Databáze: OpenAIRE
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