Establishment of the Variation of Vitamin K Status According to Vkorc1 Point Mutations Using Rat Models
| Autor: | Virginie Lattard, Sébastien Lefebvre, Etienne Benoit, Brigitte Barbier, Jean Valéry Debaux, Abdessalem Hammed, Thomas Chetot |
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| Přispěvatelé: | Rongeurs Sauvages, Risques Sanitaires et Gestion des Populations - UR 1233 (RS2GP), Institut National de la Recherche Agronomique (INRA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Vitamin medicine.medical_specialty osteocalcin lcsh:TX341-641 [SDV.TOX.TCA]Life Sciences [q-bio]/Toxicology/Toxicology and food chain 030204 cardiovascular system & hematology Vitamin k medicine.disease_cause vitamin K status vitamin K epoxide reductase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine 2. Zero hunger chemistry.chemical_classification Mutation Nutrition and Dietetics [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health biology Point mutation [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biomolecules [q-bio.BM] 030104 developmental biology Enzyme Endocrinology chemistry Osteocalcin biology.protein Vitamin K epoxide reductase VKORC1 [SDV.TOX.ECO]Life Sciences [q-bio]/Toxicology/Ecotoxicology mutation lcsh:Nutrition. Foods and food supply [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition Food Science |
| Zdroj: | Nutrients Nutrients, MDPI, 2019, 11 (9), pp.2076. ⟨10.3390/nu11092076⟩ Volume 11 Issue 9 Nutrients, Vol 11, Iss 9, p 2076 (2019) |
| ISSN: | 2072-6643 |
| Popis: | International audience; Vitamin K is crucial for many physiological processes such as coagulation, energy metabolism, and arterial calcification prevention due to its involvement in the activation of several vitamin K-dependent proteins. During this activation, vitamin K is converted into vitamin K epoxide, which must be re-reduced by the VKORC1 enzyme. Various VKORC1 mutations have been described in humans. While these mutations have been widely associated with anticoagulant resistance, their association with a modification of vitamin K status due to a modification of the enzyme efficiency has never been considered. Using animal models with different Vkorc1 mutations receiving a standard diet or a menadione-deficient diet, we investigated this association by measuring different markers of the vitamin K status. Each mutation dramatically affected vitamin K recycling efficiency. This decrease in recycling was associated with a significant alteration of the vitamin K status, even when animals were fed a menadione-enriched diet suggesting a loss of vitamin K from the cycle due to the presence of the Vkorc1 mutation. This change in vitamin K status resulted in clinical modifications in mutated rats only when animals receive a limited vitamin K intake totally consistent with the capacity of each strain to recycle vitamin K. |
| Databáze: | OpenAIRE |
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