Influence of autologous blood transfusion in liver transplantation in patients with hepatitis B on the function and hemorheology of red blood cells
| Autor: | Ying Lu, Dong-Jun Lin, Xiangfu Liu, Lihua Kuang, Rui-Fang Fan, Zhesheng Lin, Yuchan Chen, Qing Yuan |
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| Rok vydání: | 2017 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty medicine.medical_treatment Blood viscosity 030204 cardiovascular system & hematology Liver transplantation Erythrocyte aggregation Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immunology and Microbiology (miscellaneous) Internal medicine Medicine Decompensation business.industry Erythrocyte fragility Articles General Medicine Hepatitis B medicine.disease Malondialdehyde chemistry 030220 oncology & carcinogenesis Hemorheology business |
| Zdroj: | Experimental and Therapeutic Medicine. 14:1205-1211 |
| ISSN: | 1792-1015 1792-0981 |
| Popis: | The present study aimed to characterize the function and hemorheology of red blood cells (RBCs) recovered during liver transplantation surgery in patients with hepatitis B and decompensation. A total of 15 hepatitis B patients with decompensation who underwent liver transplantation surgery were included in the present study. Blood samples were recovered during the liver transplantation surgery using an Autologous Blood Recovery System. The morphology and structure of RBCs were characterized and compared between pre-operative and recovered blood samples. In addition, the physiological functions of RBCs were measured and compared between pre-operative and recovered blood samples. No significant differences in the morphological score, 2,3-diphosphoglycerate, Na+K+-ATPase, Ca2+-ATPase, Mg2+-ATPase, malondialdehyde and osmotic fragility were identified between RBCs in the pre-operative and recovered blood samples. The level of free hemoglobin in RBCs of the recovered blood samples was significantly higher than in the pre-operative blood samples (P0.05) in the low-shear blood viscosity, plasma viscosity, relative blood viscosity, erythrocyte aggregation index or Casson yield stress were identified between recovered and pre-operative blood samples. These findings suggested that autologous blood transfusion in liver transplantation surgery in patients with hepatitis B and decompensation had no significant influence on the morphology, structure, function and hemorheology of RBCs. |
| Databáze: | OpenAIRE |
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