Intrinsic apoptosis in mechanically ventilated human diaphragm: linkage to a novel Fos/FoxO1/Stat3‐Bim axis

Autor:	Myung Chang Lee, Huibin Tang, Andy Khuong, Chuong D. Hoang, Sanford Levine, Joseph B. Shrager, Sabah N. A. Hussain, Michael Vu, Murat T. Budak, Scott A Hittinger, Nicole Pietras
Rok vydání:	2011
Předmět:	Adult Male STAT3 Transcription Factor Programmed cell death Adolescent Diaphragm Apoptosis DNA Fragmentation Biology medicine.disease_cause Biochemistry Cell Line Research Communications Young Adult Proto-Oncogene Proteins Genetics medicine Respiratory muscle Humans Myocyte Molecular Biology Aged Bcl-2-Like Protein 11 Forkhead Box Protein O1 Intrinsic apoptosis Membrane Proteins Skeletal muscle Forkhead Transcription Factors Middle Aged Respiration Artificial Molecular biology Caspase 9 Mitochondria Muscle Cell biology Diaphragm (structural system) Oxidative Stress medicine.anatomical_structure Female Apoptosis Regulatory Proteins Proto-Oncogene Proteins c-fos Oxidative stress Biotechnology
Zdroj:	The FASEB Journal. 25:2921-2936
ISSN:	1530-6860 0892-6638
Popis:	Mechanical ventilation (MV) is a life-saving measure in many critically ill patients. However, prolonged MV results in diaphragm dysfunction that contributes to the frequent difficulty in weaning patients from the ventilator. The molecular mechanisms underlying ventilator-induced diaphragm dysfunction (VIDD) remain poorly understood. We report here that MV induces myonuclear DNA fragmentation (3-fold increase; P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7548c6749295a9ef05bbb2b61558748 https://doi.org/10.1096/fj.11-183798 Zobrazit plný text záznamu Plný text