Prednisone and chronic liver disease. II. Clinical versus morphological criteria for selection of patients for prednisone treatment
| Autor: | Erik Juhl, Niels Tygstrup, Poul Schlichting, Lis Fauerholdt, E. Christensen, Henrik E. Poulsen |
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| Rok vydání: | 1982 |
| Předmět: |
Liver Cirrhosis
Male medicine.medical_specialty Pathology Chronic liver disease Gastroenterology law.invention Random Allocation Sex Factors Randomized controlled trial law Prednisone Internal medicine Biopsy medicine Humans Prospective Studies Prospective cohort study Hepatitis Chronic Hepatitis Hepatology medicine.diagnostic_test business.industry medicine.disease Clinical trial Liver biopsy Chronic Disease Drug Evaluation Female business medicine.drug |
| Zdroj: | Liver. 2(2) |
| ISSN: | 0106-9543 |
| Popis: | A prospective, unblinded, randomized trial of treatment of cirrhosis and chronic aggressive hepatitis (CAH) with prednisone included 484 patients who were divided using both the clinical criteria: non-alcoholic females without ascites, and the morphological criterion: presence of a liver biopsy showing CAH. A total of 164 patients (34%) satisfied the three clinical criteria and biopsies from 95 patients (20%) showed CAH. By a cross-tabulation method between the two sets of criteria, four groups were formed. Evaluation of the treatment effect by means of relative death rate showed that the clinical criteria identified both a group of patients with a beneficial effect of prednisone (p less than 0.05) and a group with a harmful effect of the treatment (p less than 0.05). Patients with CAH also had a significant beneficial treatment effect, but patients without CAH showed only an insignificantly harmful effect of treatment. Patients fulfilling both sets of criteria had a beneficial effect of prednisone (p less than 0.05) and patients lacking both sets had a significantly harmful treatment effect. A significantly better survival was found in patients satisfying the clinical criteria without CAH in the biopsy than in patients with CAH and not fulfilling the clinical criteria (p = 0.03). In both the groups of patients with disagreement between the two sets of criteria, a trend towards a beneficial effect of prednisone was found. It is concluded that the simple clinical criteria in comparison with the histological criteria identify a larger group of patients with a beneficial effect of treatment. |
| Databáze: | OpenAIRE |
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