Circumstances of death and gross and microscopic observations in a series of 200 cases of sudden death associated with arrhythmogenic right ventricular cardiomyopathy and/or dysplasia
| Autor: | R. Loire, Daniel Malicier, Alain Tabib, Lara Chalabreysse, F. Thivolet, P. Bouvagnet, Philippe Chevalier, D. Meyronnet, A. Miras |
|---|---|
| Přispěvatelé: | Hospices Civils de Lyon (HCL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Rétrovirus et Pathologie Comparée (RPC), Institut National de la Recherche Agronomique (INRA)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Ecole Nationale Vétérinaire de Lyon (ENVL), Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Bundle of His Heart disease Adolescent [SDV]Life Sciences [q-bio] Heart Ventricles Cardiac pathology Cardiomyopathy 030204 cardiovascular system & hematology Sudden death Right ventricular cardiomyopathy Sudden cardiac death 03 medical and health sciences 0302 clinical medicine SUDDEN Physiology (medical) Internal medicine medicine Prevalence Humans 030212 general & internal medicine Child Arrhythmogenic Right Ventricular Dysplasia Aged Retrospective Studies CARDIOMYOPATHY business.industry Myocardium DEATH Retrospective cohort study Organ Size Middle Aged medicine.disease 3. Good health Death Sudden Cardiac Dysplasia TISSUE Child Preschool Cardiology Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation Circulation, American Heart Association, 2003, 108 (24), pp.3000-3005. ⟨10.1161/01.CIR.0000108396.65446.21⟩ |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/01.CIR.0000108396.65446.21⟩ |
| Popis: | Background— Sudden death is a possible consequence of arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D). Prevalence of ARVC/D in unexpected sudden cardiac death (USCD), however, remains imprecise, as do circumstances of death and ARVC/D-associated gross and microscopic findings, especially His bundle anomalies. Methods and Results— We reviewed 14 000 forensic autopsies required by judicial authorities from January 1980 to January 1999 in a 2 000 000-resident area. Age, gender, and circumstances of death were recorded. Hearts were examined macroscopically and microscopically. In this series, the ARVC/D group accounted for 200 consecutive cases (10.4%) of USCD, including 108 males and 92 females (average age 32.5 and 34.5 years, respectively). Nearly one third of deaths occurred during the fourth decade of life. Circumstances of death were various, but 75.6% occurred during everyday life events (at home, 63.1%; in the street, 6.6%; or at work, 6.1%); only 7 cases (3.5%) occurred during sports activity. Nineteen cases (9.5%) happened during the perioperative period. Adipose infiltration of the right ventricle was either isolated (20%) or associated with fibrosis (74.5%) and lymphocytes (5.5%). A total of 14.5% of cases had cardiac hypertrophy, assessed by an increase in heart weight and/or left ventricular wall thickness. In most cases, the His bundle and its branches were abnormal either because of infiltration of adipose tissue (8.1%), fibrosis (54.3%), or both (5.6%). Conclusions— In ARVC/D, both sexes are equally affected, and there is a peak of risk during the fourth decade. Death most frequently occurs during sedentary activity. His abnormalities and left ventricular hypertrophy may be associated with ARVC/D. |
| Databáze: | OpenAIRE |
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