Metabolic adaptation of intracellular bacteria and fungi to macrophages
| Autor: | Marcel Sprenger, Lydia Kasper, Bernhard Hube, Michael Hensel |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Phagocytosis Microorganism 030106 microbiology Microbiology 03 medical and health sciences Cytosol Immune system Phagosomes Animals Humans Phagosome Bacteria biology Macrophages Intracellular parasite Fungi Biological Transport Nutrients General Medicine biology.organism_classification Antimicrobial Adaptation Physiological Infectious Diseases Intracellular |
| Zdroj: | International Journal of Medical Microbiology. 308:215-227 |
| ISSN: | 1438-4221 |
| DOI: | 10.1016/j.ijmm.2017.11.001 |
| Popis: | The mature phagosome of macrophages is a hostile environment for the vast majority of phagocytosed microbes. In addition to active destruction of the engulfed microbes by antimicrobial compounds, restriction of essential nutrients in the phagosomal compartment contributes to microbial growth inhibition and killing. However, some pathogenic microorganisms have not only developed various strategies to efficiently withstand or counteract antimicrobial activities, but also to acquire nutrients within macrophages for intracellular replication. Successful intracellular pathogens are able to utilize host-derived amino acids, carbohydrates and lipids as well as trace metals and vitamins during intracellular growth. This requires sophisticated strategies such as phagosome modification or escape, efficient nutrient transporters and metabolic adaptation. In this review, we discuss the metabolic adaptation of facultative intracellular bacteria and fungi to the intracellular lifestyle inside macrophages. |
| Databáze: | OpenAIRE |
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