Fasciolicides: Efficacy, Actions, Resistance and its Management
| Autor: | Ian Fairweather, J.C. Boray |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Drug
Fascioliasis media_common.quotation_subject Drug Resistance Diamfenetide Oxidative phosphorylation Drug resistance Pharmacology Salicylanilides Sulfanilamides parasitic diseases medicine Animals Fasciola hepatica Triclabendazole media_common Anthelmintics Nitroxinil General Veterinary biology Liver fluke biology.organism_classification Microscopy Electron Tubulin Microscopy Electron Scanning biology.protein Benzimidazoles Animal Science and Zoology medicine.drug |
| Zdroj: | The Veterinary Journal. 158:81-112 |
| ISSN: | 1090-0233 |
| DOI: | 10.1053/tvjl.1999.0377 |
| Popis: | The modes of action of fasciolicides are described. Closantel and other salicylanilides interfere with energy metabolism by uncoupling oxidative phosphorylation in the fluke. Other fasciolicides are believed to have a metabolic action-halogenated phenols (via uncoupling) and clorsulon (via inhibition of glycolysis)-but direct evidence is lacking. Benzimidazoles (in particular, triclabendazole) bind to fluke tubulin and disrupt microtubule-based processes. Diamphenethide inhibits protein synthesis in the fluke. Other potential drug actions may contribute to overall drug efficacy. In particular, a number of fasciolicides-salicylanilides, phenols, diamphenethide-induce a rapid paralysis of the fluke, so their action may have a neuromuscular basis, although the actions remain ill-defined. Resistance to salicylanilides and triclabendazole has been detected in the field, although drug resistance does not appear to be a major problem yet. Strategies to minimize the development of resistance include the use of synergistic drug combinations, together with the design of integrated management programmes and the search for alternatives to drugs, in particular, vaccines. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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