Pathologies related to abnormal deposits in dermatology : a physico-chemical approach

Autor: Hester Colboc, Philippe Moguelet, Emmanuel Letavernier, Vincent Frochot, Jean-François Bernaudin, Raphaël Weil, Stéphan Rouzière, Patricia Senet, Claude Bachmeyer, Naomi Laporte, Ivan Lucas, Vincent Descamps, Reyhan Amode, Florence Brunet-Possenti, Nicolas Kluger, Lydia Deschamps, Arnaud Dubois, Solenn Reguer, Andrea Somogyi, Kadda Medjoubi, Matthieu Refregiers, Michel Daudon, Dominique Bazin
Přispěvatelé: Clinicum, Department of Dermatology, Allergology and Venereology, Helsinki University Hospital Area, HUS Inflammation Center, Refregiers, Matthieu, Hôpital Rothschild [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sorbonne Université (SU), Service d'Anatomie et cytologie pathologiques [CHU Tenon], CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service d'Explorations fonctionnelles multidisciplinaires [CHU Tenon], Maladies rénales fréquentes et rares : des mécanismes moléculaires à la médecine personnalisée (CoRaKID), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Sorbonne Université - Faculté de Médecine (SU FM), Laboratoire de Physique des Solides (LPS), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Service de dermatologie et allergologie [CHU Tenon], Service de Médecine Interne = Hôpital de jour de médecine [CHU Tenon], Laboratoire Interfaces et Systèmes Electrochimiques (LISE), Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Service de Dermatologie [Hôpital Bichat – Claude-Bernard - APHP], AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Helsinki University Central Hospital, University of Helsinki, Hôpital Xavier Bichat, Service d'anatomie et cytologie pathologiques, Assistance Publique - Hôpitaux de Paris, Laboratoire Charles Fabry / Biophotonique, Laboratoire Charles Fabry (LCF), Institut d'Optique Graduate School (IOGS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut d'Optique Graduate School (IOGS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Synchrotron SOLEIL (SSOLEIL), Centre National de la Recherche Scientifique (CNRS), Centre de biophysique moléculaire (CBM), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie Physique (ICP), Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2022
Předmět:
OPTICAL COHERENCE TOMOGRAPHY
TITANIUM-DIOXIDE NANOPARTICLES
X-RAY-FLUORESCENCE
[SDV.BBM.BP] Life Sciences [q-bio]/Biochemistry
Molecular Biology/Biophysics
Building and Construction
Dermatology
[SDV.MHEP.DERM] Life Sciences [q-bio]/Human health and pathology/Dermatology
Syn-chrotron radiation
TRANSFORM-INFRARED-SPECTROSCOPY
SCANNING-ELECTRON-MICROSCOPY
Calcification
COMBINING MU-XRF
[SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Biophysics
DENSITY-FUNCTIONAL THEORY
SYNCHROTRON-RADIATION TECHNIQUES
Vibrational spectroscopies
Electronic microscopy
3121 General medicine
internal medicine and other clinical medicine
Electrical and Electronic Engineering
ComputingMilieux_MISCELLANEOUS
[SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology
FRONTAL FIBROSING ALOPECIA
IN-VIVO
Zdroj: Comptes Rendus. Chimie
Comptes Rendus. Chimie, 2022, ⟨10.5802/crchim.153⟩
ISSN: 1631-0748
1878-1543
DOI: 10.5802/crchim.153⟩
Popis: Although numerous pathologies are associated with abnormal skin deposits, these remain poorly described, as accurate characterization continues to present a challenge for dermatologists. Their submicrometer size as well as their diverse chemistry require various characterization tools. We aim to exemplify characterization of endogenous and exogenous skin deposits in some selected skin diseases using different physico-chemical techniques. We begin with a presentation of selected dis-eases associated with skin deposits. We then present those of our results which show their variety of structure, location and chemical composition, obtained with various tools: Field Emission Scanning Electron Microscopy coupled with Energy Dispersive X-ray Spectroscopy, X-ray fluorescence, vibra-tional spectroscopies, as well as techniques specific to synchrotron radiation. Our results constitute a real opportunity to improve diagnosis, and to understand the pathogenesis of many skin diseases, and opportunities for therapeutic intervention.
Databáze: OpenAIRE
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