Anti-selective and regioselective aldol addition of ketones with aldehydes using MgI2 as promoter
| Autor: | Han-Xun Wei, Paul W. Paré, Richard L. Jasoni, Huawa Shao, Jiali Hu |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
chemistry.chemical_classification
Base (chemistry) High selectivity Organic Chemistry Regioselectivity General Medicine Combinatorial chemistry Biochemistry Magnesium iodide Coupling reaction chemistry.chemical_compound Aldol reaction chemistry Yield (chemistry) Drug Discovery Organic chemistry Amine gas treating Piperidine |
| Zdroj: | Tetrahedron. 60:11829-11835 |
| ISSN: | 0040-4020 |
| DOI: | 10.1016/j.tet.2004.09.098 |
| Popis: | The first example of a direct aldehyde–ketone coupling using the secondary amine piperidine as base in the presence of MgI2 to generate high selectivity of anti-aldol products from unmodified ethyl ketones in high yield is reported. The coupling reactions were carried out in a one-pot reaction by mixing four reaction components at room temperature. In the case of unsymmetrical ketones, addition was made to the less hindered α-side. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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