A complex satellite DNA polymorphism flanking the human ryanodine receptor gene (RYR1)
| Autor: | W. Wolz, S. Rouquier, D. Giorgi, C. R. Müller, U. Wendelmuth |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Genetics
RYR1 Polymorphism Genetic Base Sequence Satellite DNA 5' flanking region Molecular Sequence Data Muscle Proteins Ryanodine Receptor Calcium Release Channel Biology DNA Satellite Molecular biology Polymerase Chain Reaction Minisatellite Gene mapping Genetic marker Microsatellite Humans Calcium Channels Molecular Biology Gene Genetics (clinical) |
| Zdroj: | Cytogenetics and cell genetics. 72(2-3) |
| ISSN: | 0301-0171 |
| Popis: | We describe a new highly polymorphic DNA marker flanking the human ryanodine receptor gene (RYR1) at chromosome band 19ql3.1. The marker is composed of a 25-bp minisatellite sequence, a compound microsatellite (AC)(AT), and an oligo-T stretch. STS mapping of previously published markers from 19q13.1 helped to integrate the genetic and physical maps of this region. Together with D19S422, the new polymorphism forms a pair of markers closely flanking either side of the RYR1 gene which may be useful for linkage studies in families susceptible to malignant hyperthermia and central core disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|