Inhibitors of Acyl-CoA:Cholesterol O-acyltransferase (ACAT) as hypocholesterolemic agents: Synthesis and structure-activity relationships of novel series of sulfonamides, acylphosphonamides and acylphosphoramidates

Autor:	Helen T. Lee, Brian R. Krause, Bruce D. Roth, R. L. Stanfield, W. H. Roark, Joseph Armand Picard, Drago Robert Sliskovic, R. F. Bousley, K. L. Hamelehle
Rok vydání:	1998
Předmět:	medicine.drug_class Stereochemistry Clinical Biochemistry Sterol O-acyltransferase Pharmaceutical Science Carboxamide Biochemistry Chemical synthesis Structure-Activity Relationship chemistry.chemical_compound Organophosphorus Compounds Microsomes Drug Discovery medicine Animals Enzyme Inhibitors Molecular Biology chemistry.chemical_classification Sulfonamides biology Cholesterol Anticholesteremic Agents Organic Chemistry Phosphoramidate Enzyme chemistry Acyltransferases Enzyme inhibitor biology.protein Molecular Medicine Rabbits Sterol O-Acyltransferase
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 8:289-294
ISSN:	0960-894X
Popis:	Sulfoacetic acid, phosphoramidate, and phosphoramide analogs of the ACAT inhibitors, CI-999 and CI-1011 were synthesized. The structure-activity relationships of these compounds as ACAT inhibitors are described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c74ac58e97453c222e55e48824453b5e https://doi.org/10.1016/s0960-894x(98)00011-0 Zobrazit plný text záznamu Full Text from ScienceDirect