Effect of Tumor Necrosis Factor-α Gene Polymorphism on Peri-Implant Bone Loss Following Prosthetic Reconstruction
| Autor: | Wilson Roberto Sendyk, Nívea Maria de Freitas, Fábio Daumas Nunes, Julio Cesar Joly, Ney Soares de Araújo, Patricia Ramos Cury |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Alveolar Bone Loss Peri implant bone Gene Frequency Humans Medicine Allele Gene Alleles Aged Dental Implants Chi-Square Distribution Polymorphism Genetic Tumor Necrosis Factor-alpha business.industry Dental Implantation Endosseous Middle Aged Case-Control Studies Female Tumor necrosis factor alpha Dental Prosthesis Implant-Supported Gene polymorphism Oral Surgery business |
| Zdroj: | Implant Dentistry. 16:80-88 |
| ISSN: | 1056-6163 |
| Popis: | The present study investigates the association between a specific polymorphism in the tumor necrosis factor (TNF)-alpha gene, consisting of allele 2 of TNF-alpha-308, and peri-implant bone loss following prosthetic reconstruction.This case-control study included 36 patients (20 women, 16 men; mean age 46 years) who had used implant-supported prostheses for a minimum of 6 months and a maximum of 31 months. The patients were nonsmoking, white Caucasian Brazilians, in good general health, and were not receiving medication. In the case group, patients exhibited 1 or more implants with a diagnosis of peri-implant bone loss following prosthetic reconstruction; control patients had 1 or more healthy implants.Polymorphism in the TNF-alpha gene, allele 2 of TNF-alpha, was not associated with an increased risk for peri-implant bone loss following prosthetic reconstruction (P=0.19; chi2=1.71; df=1), although 21.1% of the subjects carried allele in the control group 2, and 41.2% carried allele 2 in the case group.Polymorphism in allele 2 of the TNF-alpha-308 gene is not associated with an increased risk for peri-implant bone loss following prosthetic reconstruction. However, further studies based on a greater number of patients are necessary. |
| Databáze: | OpenAIRE |
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