Levels of Prebeta‐1 High‐Density Lipoprotein Are a Strong Independent Positive Risk Factor for Coronary Heart Disease and Myocardial Infarction: A Meta‐Analysis
| Autor: | John P. Kane, Josefina Naya-Vigne, Mary J. Malloy, Clive R. Pullinger, Philip H. Frost, Patricia O’Connor, Irina Movsesyan, Steven T. Kunitake |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Myocardial Infarction Coronary Disease Coronary Artery Disease High-Density Lipoproteins Pre-beta 030204 cardiovascular system & hematology Risk Assessment 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine High-density lipoprotein Risk Factors Internal medicine Clinical Studies coronary heart disease myocardial infarction prebeta‐1 HDL medicine Coronary Heart Disease Humans Myocardial infarction Risk factor Original Research 030304 developmental biology Metabolic Syndrome 0303 health sciences business.industry Cholesterol Odds ratio Protective Factors medicine.disease reverse cholesterol transport chemistry Cohort Cardiology Metabolic syndrome apolipoprotein A‐1 Cardiology and Cardiovascular Medicine business Lipoprotein |
| Zdroj: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| ISSN: | 2047-9980 |
| Popis: | Background We previously showed that levels of prebeta‐1 high‐density lipoprotein (HDL), the principal acceptor of cholesterol effluxed from cells, including artery wall macrophages, are positively associated with coronary heart disease (CHD) and myocardial infarction (MI) risk. Methods and Results In a multiethnic follow‐up cohort of 1249 individuals from University of California–San Francisco clinics, we determined the degree to which prebeta‐1 HDL levels, both absolute and percentage of apolipoprotein AI, are associated with CHD and history of MI. Independent, strong, positive associations were found. Meta‐analysis revealed for the absolute prebeta‐1 HDL for the top tertile versus the lowest, unadjusted odds ratios of 1.90 (95% CI, 1.40–2.58) for CHD and 1.79 (95% CI, 1.35–2.36) for MI. For CHD, adjusting for established risk factors, the top versus bottom tertiles, quintiles, and deciles yielded sizable odds ratios of 2.37 (95% CI, 1.74–3.25, P P P Conclusions Analysis of 2507 subjects showed conclusively that levels of prebeta‐1 HDL are strongly associated with a history of CHD or MI, independently of traditional risk factors. Addition of prebeta‐1 HDL can significantly improve clinical assessment of risk of CHD and MI. |
| Databáze: | OpenAIRE |
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