Apathy and atrophy of subcortical brain structures in Huntington's disease: A two-year follow-up study

Autor: D Craufurd, Alexandra Durr, Verena Baake, Track-Hd Investigators, Blair R. Leavitt, Eve M. Dumas, E. van Duijn, Sarah J. Tabrizi, Rachael I. Scahill, Raymund A.C. Roos, Emma M. Coppen, S.J.A. van den Bogaard, Hans J. Johnson
Přispěvatelé: Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Service de Génétique Cytogénétique et Embryologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), University College of London [London] (UCL)
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Adult
Male
medicine.medical_specialty
Cognitive Neuroscience
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Thalamus
Apathy
Disease
Audiology
Logistic regression
lcsh:Computer applications to medicine. Medical informatics
lcsh:RC346-429
03 medical and health sciences
0302 clinical medicine
Atrophy
Huntington's disease
medicine
Humans
Radiology
Nuclear Medicine and imaging
Cognitive decline
lcsh:Neurology. Diseases of the nervous system
Aged
030214 geriatrics
business.industry
Follow up studies
Brain
Regular Article
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Huntington Disease
Logistic Models
Neurology
Disease Progression
lcsh:R858-859.7
Female
Neurology (clinical)
medicine.symptom
business
030217 neurology & neurosurgery
Follow-Up Studies
Subcortical structures
Zdroj: Neuroimage-Clinical
Neuroimage-Clinical, Elsevier, 2018, 19, pp.66-70. ⟨10.1016/j.nicl.2018.03.033⟩
NeuroImage: Clinical, Vol 19, Iss, Pp 66-70 (2018)
NeuroImage : Clinical
NeuroImage: Clinical, 19, 66-70
NeuroImage: Clinical
ISSN: 2213-1582
DOI: 10.1016/j.nicl.2018.03.033⟩
Popis: Background Huntington's disease (HD) is characterized by motor and behavioral symptoms, and cognitive decline. HD gene carriers and their caregivers report the behavioral and cognitive symptoms as the most burdensome. Apathy is the most common behavioral symptom of HD and is related to clinical measures of disease progression, like functional capacity. However, it is unknown whether apathy is directly related to the neurodegenerative processes in HD. Objective The aim is to investigate whether an association between atrophy of subcortical structures and apathy is present in HD, at baseline and after 2 years follow-up. Method Volumes of 7 subcortical structures were measured using structural T1 MRI in 171 HD gene carriers of the TRACK-HD study and apathy was assessed with the Problem Behaviors Assessment-Short, at baseline and follow-up visit. At baseline, logistic regression was used to evaluate whether volumes of subcortical brain structures were associated with the presence of apathy. Linear regression was used to assess whether subcortical atrophy was associated with the degree of apathy at baseline and with an increase in severity of apathy over time. Results At baseline, smaller volume of the thalamus showed a higher probability of the presence of apathy in HD gene carriers, but none of the subcortical structures was associated with the degree of apathy. Over time, no association between atrophy of any subcortical structures and change in degree of apathy was found. Conclusion The presence of apathy is associated with atrophy of the thalamus in HD, suggesting that apathy has an underlying neural cause and might explain the high incidence of apathy in HD. However, no association was found between atrophy of these subcortical structures and increase in severity of apathy over a 2-year time period.
Highlights • Apathy is associated with atrophy of the thalamus in HD. • Apathy is already present in the early stages of HD. • Severity of apathy does not drastically increase over a time period of 2 years.
Databáze: OpenAIRE
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