Assessment of Plasma Antioxidant Status in Hemodialysis Patients
Autor: | Mohammad Hemmati, Mitra Mahdavi-Mazde, Mehri Kadkhodaee, Maryam Zahmatkesh, Behjat Seifi, Rana Ghaznavi, Fatemeh Mirershadi |
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Rok vydání: | 2008 |
Předmět: |
Adult
Male medicine.medical_specialty Antioxidant medicine.medical_treatment Iran medicine.disease_cause Ferric Compounds Gastroenterology Antioxidants chemistry.chemical_compound Renal Dialysis Malondialdehyde Internal medicine medicine Humans Vitamin E Dialysis business.industry Cancer Hematology Glutathione Middle Aged medicine.disease Surgery Oxidative Stress chemistry Nephrology Case-Control Studies Female Hemodialysis business Oxidation-Reduction Oxidative stress |
Zdroj: | Therapeutic Apheresis and Dialysis. 12:147-151 |
ISSN: | 1744-9987 1744-9979 |
DOI: | 10.1111/j.1744-9987.2008.00561.x |
Popis: | The risk of atherosclerosis and cancer is high in patients on hemodialysis. A breakdown in the natural balance between the activity of the body's antioxidant system and the production of oxidizing agents is suggested to be involved. To investigate the oxidative stress status in Iranian hemodialytic patients, in this study we evaluated plasma vitamin E, malondialdehyde (MDA), reduced glutathione (GSH), and ferric reducing antioxidant power (FRAP) levels in these patients. Twenty-four hemodialytic patients and 24 control subjects (age and sex matched) were included in this study. Each patient was under dialysis, three times per week, four hours in each session. Before and after dialysis, blood was taken for biochemical measurements as well as oxidative stress tests. There was a significant decrease in FRAP and GSH levels after dialysis comparing to before treatment levels. MDA was increased by dialysis and vitamin E levels were less in dialytic patients, both before and after treatment, compared to controls. This study indicates that there is a significant level of oxidative stress in chronic renal patients and this stress is augmented by dialysis. Antioxidant therapy could be considered in these patients. |
Databáze: | OpenAIRE |
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