Maternal diet fatty acid composition affects neurodevelopment in rat pups
| Autor: | Janet E. Stockard, Li T. Chen, Jane D. Carver, Valerie J. Benford, Christopher P. Phelps, Monisha D. Saste |
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| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Reflex Startle Auditory Pathways Neural Conduction Medicine (miscellaneous) Biology Nervous System Rats Sprague-Dawley Pregnancy Internal medicine Lactation medicine Animals chemistry.chemical_classification Nutrition and Dietetics Fatty Acids Maternal effect Menhaden Fatty acid biology.organism_classification Fish oil Diet Rats Endocrinology medicine.anatomical_structure chemistry Animals Newborn Gestation Pregnancy Animal Female Corn oil Polyunsaturated fatty acid Brain Stem |
| Zdroj: | The Journal of nutrition. 128(4) |
| ISSN: | 0022-3166 |
| Popis: | The effect of pre- and postnatal maternal dietary fatty acid composition on neurodevelopment in rat pups was studied. Timed pregnant dams were fed, beginning on d 2 of gestation and throughout lactation, either nonpurified diet (reference) or a purified diet whose fat source (22% of energy) was either corn oil or menhaden fish oil. On postnatal d 3, pups were randomly cross-fostered among dams of the same diet group and culled to 10 pups per dam. Milk was removed from stomachs of culled pups for fatty acid analyses. From postnatal d 4 to 30, pups were assessed daily for the appearance of neurodevelopmental reflexes. Auditory brainstem conduction times were measured on postnatal d 23 and 29. Pups were killed on postnatal d 30, and cerebrums were removed for fatty acid analyses. The fatty acid composition of maternal milk and pup cerebrums reflected maternal diet with higher levels of (n-3) and (n-6) fatty acids in the fish oil and corn oil groups, respectively. The time of appearance of auditory startle was significantly delayed (P = 0.004), and auditory brainstem conduction times on postnatal d 23 and 29 were significantly longer in pups of the fish oil- than corn oil-fed dams (P < 0.05). A delay in the appearance of the auditory startle reflex and longer auditory brainstem conduction times in pups of dams fed fish oil-supplemented diet may be due to negative effects on myelination of the auditory brainstem pathway. J. |
| Databáze: | OpenAIRE |
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