Cerebral toxoplasmosis in HIV-infected patients over 2015–2018 (a case study of Russia)
| Autor: | T N Trofimova, E. G. Bakulina, E A Viktorova, O. V. Azovtseva, A. S. Shelomov |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Epidemiology Central nervous system medical imaging Autopsy Physical examination HIV Infections law.invention Russia 03 medical and health sciences 0302 clinical medicine law Medicine Humans 030212 general & internal medicine Polymerase chain reaction Cerebral toxoplasmosis Original Paper Cluster of differentiation medicine.diagnostic_test AIDS-Related Opportunistic Infections business.industry Incidence (epidemiology) Viral Load HIV infection clinical picture Infectious Diseases medicine.anatomical_structure pathoanatomy Toxoplasmosis Cerebral Female business Viral load 030217 neurology & neurosurgery |
| Zdroj: | Epidemiology and Infection |
| ISSN: | 1469-4409 0950-2688 |
| Popis: | Cerebral toxoplasmosis is a leading cause of the central nervous system disorders in acquired immune deficiency syndrome. This study aimed to investigate the clinical course of cerebral toxoplasmosis in human immunodeficiency virus (HIV)-infected individuals. The study included 90 HIV-infected patients with cerebral toxoplasmosis, who underwent inpatient treatment. In case of positive enzyme immunoassay, HIV infection was confirmed with the immunoblot test. The HIV-1 ribonucleic acid level was determined using the polymerase chain reaction method. The flow cytometry was used for counting CD4 (cluster of differentiation 4 cells). Pathomorphological examination included the autopsy, gross and microscopic examination of internal organs, histological and other methods. The incidence of cerebral toxoplasmosis significantly increases at the CD4 count below 100 cells/μl, P < 0.001, and at the HIV viral load above 50 copies/ml, P < 0.05. The clinical picture of cerebral toxoplasmosis included focal symptoms, cognitive impairment, toxic syndrome, mild cerebral symptoms and a meningeal symptom. Given the absence of a specific clinical picture and the absence of abnormal laboratory and instrumental findings, the cerebral toxoplasmosis needs to be diagnosed with a number diagnostic methods combined: clinical examination, laboratory testing, immunological examination, molecular genetic testing and neuroradiological imaging. |
| Databáze: | OpenAIRE |
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