Anti-inflammatory and antinociceptive effects of the stem bark of Byrsonima intermedia A. Juss
| Autor: | Fabiana C. Vilela, Alexandre Giusti-Paiva, Geraldo Alves-da-Silva, Danielle Ferreira Dias, Lidiane Orlandi, Flávia V. Santa-Cecília |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Nociception
Lipopolysaccharides Male Hot Temperature Time Factors Narcotic Antagonists Byrsonima intermedia Anti-Inflammatory Agents (+)-Naloxone Pharmacology Carrageenan Mice Opioid receptor Drug Discovery Edema Medicine Chromatography High Pressure Liquid Pain Measurement Analgesics Behavior Animal Plant Stems biology Naloxone Granuloma Foreign-Body Anesthesia Plant Bark Byrsonima medicine.symptom Malpighiaceae Pain Threshold medicine.drug_class Pain Inflammation Motor Activity Peritonitis Anti-inflammatory Phenols In vivo Formaldehyde Animals Cotton Fiber Rats Wistar Flavonoids Plants Medicinal Dose-Response Relationship Drug Plant Extracts business.industry Antagonist biology.organism_classification Rats Disease Models Animal business |
| Zdroj: | Journal of Ethnopharmacology. 137:1469-1476 |
| ISSN: | 0378-8741 |
| Popis: | a b s t r a c t Ethnopharmacological relevance: Byrsonima intermedia A. Juss. is popularly known as "murici pequeno" and is native to the Brazilian Cerrado. This species has been used as an antimicrobial, anti-hemorrhagic, anti- diarrheal and anti-inflammatory. Nevertheless, scientific information regarding Byrsonima intermedia is limited; there are no reports related to its possible anti inflammatory and antinociceptive effects. This study employed in vivo inflammatory and nociceptive models to evaluate the scientific basis for the traditional use of Byrsonima intermedia. Materials and methods: Carrageenan-induced paw edema, peritonitis and fibrovascular tissue growth induced by s.c. cotton pellet implantation tests were used to investigate the anti-inflammatory activity of Byrsonima intermedia aqueous extract (BiAE) in rats. Mechanical nociceptive paw, formalin and hot plate tests were used to evaluate the antinociceptive activity in mice. High-performance liquid chromatography (HPLC), phytochemistry screening and determination of total phenolics and flavonoids were used to determine the chemical profile of the BiAE. Results: BiAE at test doses of 30-300 mg/kg p.o. clearly demonstrated anti-inflammatory effects by reduced carrageenan-induced paw edema, by inhibited leukocyte recruitment into the peritoneal cavity and, in the model of chronic inflammation, by using the cotton pellet-induced fibrovascular tissue growth in rats. The extracts at test doses of 30-300 mg/kg p.o. clearly demonstrated antinociceptive activity in all tests. Administration of the opioid receptor antagonist naloxone completely inhibited the antinociceptive effect induced by BiAE (100 mg/kg). Conclusion: BiAE markedly exhibits anti-inflammatory action in rats and antinociceptive activity in mice. Thus, it may be useful in the treatment of inflammatory hyperalgesic disorders, which supports previous claims of its traditional use. © 2011 Elsevier Ireland Ltd. |
| Databáze: | OpenAIRE |
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