Levofloxacin: serum bactericidal activity against methicillin-resistant Staphylococcus aureus isolates
| Autor: | C Muller-Serieys, C Carbon, C Bigot, C Benoit, B Maubert, D Decré |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Microbiology (medical)
Ofloxacin Staphylococcus aureus Meticillin Levofloxacin Microbial Sensitivity Tests medicine.disease_cause Microbiology Serum Bactericidal Test Anti-Infective Agents medicine Humans heterocyclic compounds Pharmacology (medical) Pharmacology Minimum bactericidal concentration business.industry biochemical phenomena metabolism and nutrition bacterial infections and mycoses Methicillin-resistant Staphylococcus aureus Infectious Diseases Methicillin Resistance Methicillin Susceptible Staphylococcus Aureus business medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 43:67-70 |
| ISSN: | 1460-2091 0305-7453 |
| DOI: | 10.1093/jac/43.suppl_3.67 |
| Popis: | The aim of this study was to assess the serum bactericidal activity (SBA) of levofloxacin compared with that of ofloxacin against methicillin-resistant Staphylococcus aureus (MRSA) isolates. Serum from 10 healthy volunteers (seven females, three males) was collected after a single oral dose of either levofloxacin (500 mg) or ofloxacin (400 mg). Subjects were allocated randomly to treatment after at least a 1 week interval between antibiotic regimens. Three well-defined MRSA strains were tested, each susceptible to levofloxacin and ofloxacin, with different levels of resistance to methicillin (HBD 456, HBD 3 and HBD 2; class 1, 2 and 3 Tomasz heterogeneous resistance, respectively) together with a methicillin-susceptible (MSSA) reference strain ( S. aureus ATCC 25923). SBA was tested in vitro by a microtitration method 15 min before dosing and at 1, 4, 8 and 12 h after drug absorption. Levofloxacin was significantly more bactericidal than ofloxacin against all strains of S. aureus tested (SBA ≥1:2). An SBA was recorded for only a short period with ofloxacin, and thereafter only bacteriostatic activity remained. This study, therefore, confirms the superior activity of levofloxacin over that of ofloxacin against MSSA and MRSA. |
| Databáze: | OpenAIRE |
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