Reduction in amino-acid-induced anti-hypothermic effects during general anesthesia in ovariectomized rats with progesterone replacement
| Autor: | Masahiro Kanazawa, Mariko Watanabe, Toshiyasu Suzuki |
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| Rok vydání: | 2015 |
| Předmět: |
Methyl Ethers
0301 basic medicine medicine.medical_specialty medicine.drug_class Ovariectomy medicine.medical_treatment Hypothermia Anesthesia General Sevoflurane Rats Sprague-Dawley 03 medical and health sciences Anesthesiology parasitic diseases medicine Animals Amino Acids Phosphorylation Saline Progesterone chemistry.chemical_classification Estradiol business.industry Rats Amino acid 030104 developmental biology Anesthesiology and Pain Medicine chemistry Estrogen Anesthesia Ovariectomized rat Female medicine.symptom business Hormone medicine.drug |
| Zdroj: | Journal of Anesthesia. 30:123-131 |
| ISSN: | 1438-8359 0913-8668 |
| DOI: | 10.1007/s00540-015-2075-z |
| Popis: | The aim of the present study was to determine whether the ovarian hormones, estrogen and progesterone, had different influences on amino-acid-induced anti-hypothermic effects during general anesthesia. Ovariectomized Sprague–Dawley female rats were divided into four groups: those administered 17β-estradiol plus saline or an amino acid mixture (E2-Sal and E2-AA, respectively) and progesterone plus saline or an amino acid mixture (P-Sal and P-AA, respectively). Five weeks after ovariectomy, rats were given either E2 or P and then administered either Sal or AA solution for 180 min during anesthesia with sevoflurane. Rectal temperatures were measured. Rectal temperatures were significantly higher in the E2-AA group than in the E2-Sal group 165 and 180 min after initiating the infusion of the test solutions. However, no significant differences were observed between the P-treated groups. The phosphorylation of 4E-BP1 and S6K1 was significantly greater in the E2-AA group than in the E2-Sal group (P |
| Databáze: | OpenAIRE |
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