Cerebral Cortical Gyrification: A Preliminary Investigation in Temporal Lobe Epilepsy
| Autor: | Kevin Murphy, Sinead Maguire, Colin P. Doherty, Cathy Scanlon, Lisa Ronan, Norman Delanty, Mary Fitzsimons |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Stereology Functional Laterality Temporal lobe Cohort Studies Central nervous system disease Epilepsy Imaging Three-Dimensional Sex Factors Image Processing Computer-Assisted medicine Humans Age of Onset Gyrification Cerebral atrophy Brain Mapping medicine.disease Magnetic Resonance Imaging Temporal Lobe Epilepsy Temporal Lobe Neurology Cohort Female Secondarily generalized seizures Neurology (clinical) Atrophy Psychology |
| Zdroj: | Epilepsia. 48:211-219 |
| ISSN: | 1528-1167 0013-9580 |
| Popis: | Summary: Purpose: To introduce a measure of global cortical folding in epilepsy by using stereology. Subtle developmental abnormalities associated with temporal lobe epilepsy may encompass brain morphologic changes such as an aberrant degree of cortical folding. Methods: Stereologic methods of volume and surface-area estimation were applied to in vivo MR brain-image data of a cohort of 20 temporal lobe epilepsy (TLE) patients (10 men, 10 women), and 20 neurologically normal controls (10 men, 10 women). Indices of cerebral gyrification and cerebral atrophy were generated. The impact of side of seizure onset, age at onset, history of febrile seizures, presence or absence of lesions, and presence or absence of secondarily generalized seizures on cerebral gyrification was assessed. Results: Although no significant group mean difference was found in the degree of cerebral gyrification between patients and controls, five of 10 of male patients had an abnormal gyrification when compared with male controls. One female patient had a significant change in gyrification compared with female controls. In general, patients with TLE demonstrated a significant degree of global cerebral atrophy compared with controls. Clinical factors were not demonstrated to affect significantly any of the quantitative parameters. Conclusions: The results of this study suggest that an aberrant degree of global cerebral gyrification may occur in certain clinical groups of TLE patients. These findings have implications for general theories of developmental susceptibility in TLE. |
| Databáze: | OpenAIRE |
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