Antigenic variation of neutralization-sensitive epitopes of caprine arthritis-encephalitis lentivirus during persistent arthritis
Autor: | Travis C. McGuire, Linda K. Norton, William P. Cheevers, Katherine I. O'Rourke |
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Jazyk: | angličtina |
Rok vydání: | 1988 |
Předmět: |
Visna-maedi virus
Immunology Arthritis Antibodies Viral Microbiology Epitope Virus Neutralization Epitopes Neutralization Tests Recurrence Virology medicine Antigenic variation Animals Neutralizing antibody Caprine arthritis encephalitis Arthritis Infectious biology Goats virus diseases medicine.disease Antigenic Variation Insect Science biology.protein Research Article Retroviridae Infections |
Popis: | Caprine arthritis-encephalitis virus (CAEV), a naturally occurring lentivirus of goats, causes disease characterized by virus persistence and recurrent arthritis. These studies demonstrate in vitro neutralization of CAEV infectivity by serum from goats infected with CAEV. Serum neutralizing activity was not detectable until 10 to 36 months postinfection, and titers were relatively low (less than or equal to 1:8). Serum neutralization was caused by antibody and was virus specific. Antigenic variants of CAEV were isolated from cell-free joint fluid of arthritic goats 9 to 18 months postinfection. The delayed appearance of neutralizing antibody and the subsequent development of antigenic variants may promote CAEV persistence in vivo and provide a stimulus for recurrent arthritis. |
Databáze: | OpenAIRE |
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