Clinical significance of platelet derived growth factor-C and -D in gastric cancer
| Autor: | Keiji Kato, Kenichi Sugihara, Norihito Ogawa, Kazuyuki Kojima, Mikito Inokuchi, Yoko Takagi, Hirofumi Sugita |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Oncogene Angiogenesis gastric cancer Hazard ratio Cancer Articles Biology medicine.disease Molecular medicine Metastasis platelet-derived growth factor D platelet-derived growth factor C Tumor progression Internal medicine medicine Histopathology prognosis |
| Zdroj: | Oncology Letters |
| ISSN: | 1792-1074 |
| Popis: | Platelet-derived growth factor (PDGF)-C and PDGF-D are frequently upregulated in human cancers and play important roles in tumor progression, angiogenesis and metastasis. However, the distribution, frequency and prognostic value of PDGF-C and PDGF-D expression in gastric cancer have not been clarified. The present study evaluated the association between expression of PDGF-C and PDGF-D, clinicopathological factors and outcomes, in patients with gastric cancer. Gastric adenocarcinoma tumor samples were obtained from 204 patients who underwent curative gastrectomy between 2003 and 2007. The expression of PDGF-C and PDGF-D was analyzed by immunohistochemical staining. High expression of PDGF-C and PDGF-D was detected in 114 (56%) and 151 (74%) tumors, respectively. PDGF-D expression was significantly associated with tumor depth (P=0.039), histopathology (P |
| Databáze: | OpenAIRE |
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