Familial Pemphigus vulgaris
| Autor: | Michael David, Varda Katzenelson, Carlos Idises, Rina Zamir, Miriam Sandbank, Juan Mellibovsky |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Fluorescent Antibody Technique Dermatology Disease Human leukocyte antigen Pathogenesis Disease susceptibility HLA Antigens Recurrence immune system diseases Humans Medicine skin and connective tissue diseases business.industry Haplotype Pemphigus vulgaris Complement C3 Middle Aged medicine.disease Pedigree Immunoglobulin G Jews Immunology Prednisone Female business Pemphigus Major histocompatibility |
| Zdroj: | Dermatology. 181:48-50 |
| ISSN: | 1421-9832 1018-8665 |
| DOI: | 10.1159/000247860 |
| Popis: | Familial pemphigus vulgaris was found in a Jewish woman and her son who developed the disease within a period of 18 months from one another. HLA typing was performed in the mother and son as well as in the unaffected father and sister. Examination of the HLA antigens in this family indicates that there may be different variants of DR4, DQw3 and that one of them carried by the mother and son as part of the haplotype A30, B18, DR4, DQw3 is associated with pemphigus vulgaris. Our findings are in favor of the concept that particular polymorphic residues of class II major histocompatibility molecules are correlated with disease susceptibility. |
| Databáze: | OpenAIRE |
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