Effect of multi-strain probiotic (UB0316) in weight management in overweight/obese adults: a 12-week double blind, randomised, placebo-controlled study
| Autor: | N. Jayanthi, Anirudh Tripathi, Jayesh J. Ahire, M. Ratna Sudha, Satyavrat Nanal |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Adult Male medicine.medical_specialty Lactobacillus casei Placebo-controlled study Overweight Bifidobacterium breve Placebo Microbiology Body Mass Index 03 medical and health sciences 0302 clinical medicine Double-Blind Method Internal medicine Medicine Humans Obesity Aged medicine.diagnostic_test biology Bacillus coagulans business.industry Waist-Hip Ratio Lactobacillus salivarius Probiotics Body Weight Middle Aged biology.organism_classification medicine.disease Lactobacillus 030104 developmental biology 030211 gastroenterology & hepatology Female medicine.symptom business Lipid profile Body mass index |
| Zdroj: | Beneficial microbes. 10(8) |
| ISSN: | 1876-2891 |
| Popis: | This clinical trial was carried out to assess the effects of multi-strain probiotic capsule (UB0316: Lactobacillus salivarius UBLS-22, Lactobacillus casei UBLC-42, Lactobacillus plantarum, UBLP-40, Lactobacillus acidophilus UBLA-34, Bifidobacterium breve UBBr-01, Bacillus coagulans Unique IS2 5×109 cfu each and fructo-oligosaccharide, 100 mg) on overweight/obesity-related parameters. Ninety subjects (age, 30-65 years; body mass index (BMI), 25-32 kg/m2) were randomised into two groups, i.e. UB0316 (probiotic) and placebo (excipient maltodextrin). They were instructed to take 2 capsules (UB0316 or placebo) per day after meals for 12 weeks. Primary (BMI), and secondary (waist-to-hip ratio: WHR; body weight, body fat; sugar and lipid profile) endpoint measures were evaluated at scheduled visits. Vital signs, physical investigations, quality of life, physician/subjects global assessment and adverse events were also recorded. A total of 71 subjects completed the scheduled study visits and analysis thereof showed that a 12-week UB0316 supplementation significantly reduced BMI (95% CI: -0.64, -0.27; P=0.0001), body weight (95% CI: -1.16, -0.50; P |
| Databáze: | OpenAIRE |
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