Brain metabolic differences between sporadic and familial Alzheimer's disease

Autor:	Alberto Pupi, Siro Bagnoli, M. T. R. De Cristofaro, Karl Herholz, Benedetta Nacmias, Elena Cellini, Sandro Sorbi, Mozghan Fayyaz, Lisa Mosconi, Laura Bracco
Rok vydání:	2003
Předmět:	Male medicine.medical_specialty Central nervous system Neuropsychological Tests Central nervous system disease Degenerative disease Alzheimer Disease Fluorodeoxyglucose F18 Reference Values Internal medicine Cortex (anatomy) medicine Humans Genetic Testing Age of Onset Genetic testing Aged Aged 80 and over medicine.diagnostic_test Brain Middle Aged medicine.disease medicine.anatomical_structure Endocrinology Glucose Phenotype Posterior cingulate Female Neurology (clinical) Age of onset Alzheimer's disease Psychology Neuroscience Tomography Emission-Computed
Zdroj:	Scopus-Elsevier
ISSN:	1526-632X
Popis:	This FDG-PET study with SPM99 compared 46 patients with sporadic Alzheimer disease (SAD) to 40 patients with familial AD (FAD) and to 35 matched controls. AD groups had equivalent metabolic (METglu) reductions in several cortical and limbic areas with respect to the controls. Patients with FAD showed decreased METglu in the posterior cingulate, parahippocampal, and occipital cortex as compared to the patients with SAD (p < 0.001). Genetic factors lead to phenotypic differences in AD.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c728d51ba827daebb66bf92b0fc71ee1 https://pubmed.ncbi.nlm.nih.gov/14581683 Zobrazit plný text záznamu