Narcolepsy type 1 features across the life span: age impact on clinical and polysomnographic phenotype
| Autor: | Michele Terzaghi, Marco Filardi, Giuseppe Plazzi, Michelangelo Maestri, Elena Antelmi, Raffaele Ferri, Andrea Romigi, Filomena I.I. Cosentino, Enrica Bonanni, Sara Marelli, Oliviero Bruni, Luigi Ferini-Strambi, Althea Lividini, Raffaele Manni, Biancamaria Guarnieri, Stefano Vandi, Francesca Ingravallo, Fabio Pizza |
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| Přispěvatelé: | Lividini A., Pizza F., Filardi M., Vandi S., Ingravallo F., Antelmi E., Bruni O., Cosentino F.I.I., Ferri R., Guarnieri B., Marelli S., Ferini-Strambi L., Romigi A., Bonanni E., Maestri M., Terzaghi M., Manni R., Plazzi G. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Pulmonary and Respiratory Medicine Pediatrics medicine.medical_specialty Delayed Diagnosis Adolescent Cataplexy diagnosis Longevity Neurological disorder age-related difference in NT1 sleepiness Young Adult medicine Humans Young adult Child Aged Narcolepsy Cross-Sectional Studie Sleepine Life span cataplexy business.industry Delayed Diagnosi narcolepsy type 1 (NT1) Middle Aged medicine.disease Scientific Investigations Phenotype Cross-Sectional Studies emotional triggers Neurology Nocturnal sleep Neurology (clinical) patient narcolepsy type 1 nocturnal sleep medicine.symptom business Emotional trigger Human |
| Zdroj: | J Clin Sleep Med |
| Popis: | STUDY OBJECTIVES: Narcolepsy type 1 (NT1) is a chronic neurological disorder typically arising during adolescence and young adulthood. Recent studies demonstrated that NT1 presents with age-specific features, especially in children. With this study we aimed to describe and to compare the clinical pictures of NT1 in different age groups. METHODS: In this cross-sectional, multicenter study, 106 untreated patients with NT1 enrolled at the time of diagnosis underwent clinical evaluation, a semistructured interview (including the Epworth Sleepiness Scale), nocturnal video-polysomnography, and the Multiple Sleep Latency Test. Patients were enrolled in order to establish 5 age-balanced groups (childhood, adolescence, adulthood, middle age, and senior). RESULTS: The Epworth Sleepiness Scale score showed a significant increase with age, while self-reported diurnal total sleep time was lower in older and young adults, with the latter also complaining of automatic behaviors in more than 90% of patients. Children reported the cataplexy attacks to be more frequent (> 1/d in 95% of patients). “Recalling an emotional event,” “meeting someone unexpectedly,” “stress,” and “anger” were more frequently reported in adult and older adult patients as possible triggers of cataplexy. Neurophysiological data showed a higher number of sleep-onset rapid eye movement periods on the Multiple Sleep Latency Test in adolescent compared to senior patients and an age-progressive decline in sleep efficiency. CONCLUSIONS: Daytime sleepiness, cataplexy features and triggers, and nocturnal sleep structure showed age-related difference in patients with NT1; this variability may contribute to diagnostic delay and misdiagnosis. CITATION: Lividini A, Pizza F, Filardi M, et al. Narcolepsy type 1 features across the life span: age impact on clinical and polysomnographic phenotype. J Clin Sleep Med. 2021;17(7):1363–1370. |
| Databáze: | OpenAIRE |
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