Acute effects of cocaine and cannabis on reversal learning as a function of COMT and DRD2 genotype

Autor: Ellen R.A. de Bruijn, Barbara Franke, Roshan Cools, Desirée Spronk, Johannes G. Ramaekers, Robbert J. Verkes, Marieke E. van der Schaaf, Janelle H. P. van Wel
Přispěvatelé: RS: FPN NPPP II, Neuropsychology & Psychopharmacology
Rok vydání: 2015
Předmět:
Male
DRD2 Taq1A
Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13]
Neuropsychological Tests
Pharmacology
Spatial memory
0302 clinical medicine
Cocaine
Reversal learning
PARKINSONS-DISEASE
Attention
Original Investigation
TRAIT IMPULSIVITY
biology
STRIATAL DOPAMINE
Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3]
DOPAMINE-RECEPTOR GENE
SPATIAL WORKING-MEMORY
Female
Psychology
Human
rs4680
Adult
THC
Adolescent
Substance-Related Disorders
education
Catechol O-Methyltransferase
Affect (psychology)
Placebo
Young Adult
03 medical and health sciences
Double-Blind Method
Punishment
Reward
Dopamine receptor D2
RESPONSE PERSEVERATION
Humans
INHIBITORY CONTROL
Polymorphism
Cannabis
Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7]
HEALTHY-YOUNG ADULTS
Catechol-O-methyl transferase
Receptors
Dopamine D2
Genetic Variation
D2 DOPAMINE
biology.organism_classification
Crossover study
030227 psychiatry
COMT Val108/158Met
CATECHOL-O-METHYLTRANSFERASE
Individual differences
170 000 Motivational & Cognitive Control
030217 neurology & neurosurgery
Zdroj: Psychopharmacology, 233, 199-211
Psychopharmacology, 233(2), 199-211. Springer
Psychopharmacology
Psychopharmacology, 233, 2, pp. 199-211
ISSN: 1432-2072
0033-3158
DOI: 10.1007/s00213-015-4141-5
Popis: Rationale Long-term cannabis and cocaine use has been associated with impairments in reversal learning. However, how acute cannabis and cocaine administration affect reversal learning in humans is not known. Objective In this study, we aimed to establish the acute effects of administration of cannabis and cocaine on valence-dependent reversal learning as a function of DRD2 Taq1A (rs1800497) and COMT Val108/158Met (rs4680) genotype. Methods A double-blind placebo-controlled randomized 3-way crossover design was used. Sixty-one regular poly-drug users completed a deterministic reversal learning task under the influence of cocaine, cannabis, and placebo that enabled assessment of both reward- and punishment-based reversal learning. Results Proportion correct on the reversal learning task was increased by cocaine, but decreased by cannabis. Effects of cocaine depended on the DRD2 genotype, as increases in proportion correct were seen only in the A1 carriers, and not in the A2/A2 homozygotes. COMT genotype did not modulate drug-induced effects on reversal learning. Conclusions These data indicate that acute administration of cannabis and cocaine has opposite effects on reversal learning. The effects of cocaine, but not cannabis, depend on interindividual genetic differences in the dopamine D2 receptor gene. Electronic supplementary material The online version of this article (doi:10.1007/s00213-015-4141-5) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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