Mechanisms of Neuroprotective Action of Hesperetin and Carnosine in Focal Ischemia of the Brain in Rats
| Autor: | V A Tutelyan, Tatiana N. Fedorova, S L Stvolinskii, A A Devyatov, D S Berezhnoy |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Ischemia Carnosine Oxidative phosphorylation Pharmacology medicine.disease_cause Neuroprotection General Biochemistry Genetics and Molecular Biology Brain Ischemia 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Animals Rats Wistar Hesperidin Penumbra Hesperetin Brain General Medicine medicine.disease Rats Neuroprotective Agents 030104 developmental biology medicine.anatomical_structure chemistry Cerebral cortex 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 169:242-245 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | We compared the direct neuroprotective effect of minor food components, antioxidants hesperetin and carnosine, and analyzed their influence on the parameters of the oxidative status of the penumbra zones in the cerebral cortex during focal ischemia (1 h) of with reperfusion in Wistar rats. The animals received hesperetin and carnosine included in the diet in daily doses of 50 and 150 mg/kg, respectively, for 7 days before ischemia induction. The neuroprotective effect of hesperetin manifested in reduction of the ischemic lesion size by 30%, which was comparable with the effect of carnosine. Both hesperetin and carnosine reduced the level of MDA in the penumbra zone of the cerebral cortex and increased the total antioxidant activity of the brain tissue. Hesperetin also increased SOD activity to a level observed in the sham-operated control group. |
| Databáze: | OpenAIRE |
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