Differential effects of actinomycin D on nucleic acid and protein synthesis in rat liver
| Autor: | R.L. Imblum, L. Prosky, R. G. O'Dell, B. Roberts |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
Male
Orotic Acid Carbon Isotopes medicine.drug_class Chemistry Antibiotics Biophysics Tritium Biochemistry Molecular biology Differential effects Rats Liver Leucine Protein Biosynthesis Rat liver Centrifugation Density Gradient Dactinomycin medicine Nucleic acid Protein biosynthesis Animals RNA Molecular Biology |
| Zdroj: | Archives of Biochemistry and Biophysics. 126:393-398 |
| ISSN: | 0003-9861 |
| DOI: | 10.1016/0003-9861(68)90423-2 |
| Popis: | Levels of actinomycin D which block up to 90% of RNA synthesis in liver inhibit protein synthesis by 40%. A 50% inhibition of RNA synthesis is accompanied by less than a 5% inhibition of protein synthesis. These results indicate that the effects of actinomycin D on protein synthesis may be only partially related to the antibiotic effects on RNA synthesis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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