A comparative physicochemical, morphological and magnetic study of silane-functionalized superparamagnetic iron oxide nanoparticles prepared by alkaline coprecipitation
| Autor: | Sophie Laurent, Laura Karina Mireles, Dimitri Stanicki, Edward Sacher, L'Hocine Yahia |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Materials science
Chemical Phenomena Coprecipitation Analytical chemistry 02 engineering and technology 010402 general chemistry 01 natural sciences Biochemistry chemistry.chemical_compound X-ray photoelectron spectroscopy Chemical Precipitation Fourier transform infrared spectroscopy Magnetite Nanoparticles Magnetite Silanes Magnetic Phenomena Cell Biology Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology Silane 0104 chemical sciences chemistry Chemical engineering Drug delivery Surface modification 0210 nano-technology |
| Zdroj: | The International Journal of Biochemistry & Cell Biology. 75:203-211 |
| ISSN: | 1357-2725 |
| DOI: | 10.1016/j.biocel.2015.12.002 |
| Popis: | The characterization of synthetic superparamagnetic iron oxide nanoparticle (SPION) surfaces prior to functionalization is an essential step in the prediction of their successful functionalization, and in uncovering issues that may influence their selection as magnetically targeted drug delivery vehicles (prodrugs). Here, three differently functionalized magnetite (Fe3O4) SPIONs are considered. All were identically prepared by the alkaline coprecipitation of Fe(2+) and Fe(3+) salts. We use X-ray photoelectron spectroscopy, electron microscopy, time-of-flight SIMS, FTIR spectroscopy and magnetic measurements to characterize their chemical, morphological and magnetic properties, in order to aid in determining how their surfaces differ from those prepared by Fe(CO)5 decomposition, which we have already studied, and in assessing their potential use as drug delivery carriers. |
| Databáze: | OpenAIRE |
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