Serum dehydroepiandrosterone and cortisol measurements in Huntington's chorea
| Autor: | Elmar Windhager, F. Reisecker, Wilma Maschek, C. Neubauer, Friedrich Leblhuber, F.X. Steinparz, Marianne Peichl |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class Dehydroepiandrosterone chemistry.chemical_compound Dehydroepiandrosterone sulfate Internal medicine medicine Humans Hydrocortisone Tomography Emission-Computed Single-Photon business.industry Antiglucocorticoid Chorea Androgen Cortisone Endocrinology Huntington Disease Neurology chemistry Neurology (clinical) medicine.symptom business Tomography X-Ray Computed hormones hormone substitutes and hormone antagonists Glucocorticoid medicine.drug |
| Zdroj: | Journal of the neurological sciences. 132(1) |
| ISSN: | 0022-510X |
| Popis: | Serum levels of dehydroepiandrosterone sulfate (DHEAS), known to antagonize metabolic effects of glucocorticoids in animals, and cortisol (CRT), already shown to be related to cognitive dysfunction in man and animals, were measured in 11 drug-free male subjects with definite Huntington's chorea (HC) and in 25 age-matched male normal controls. Statistical difference was found between DHEAS serum levels (p < 0.05), CRT levels (p < 0.05) and the DHEAS/CRT ratio (p < 0.01) of HC subjects and normal individuals. These findings may indicate a dysfunction of the hypothalamic-pituitary-adrenal axis (HPAA) and possibly suggest a role of DHEAS as an antiglucocorticoid in HC. |
| Databáze: | OpenAIRE |
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