Transphyseal Bioabsorbable Screws Cause Temporary Growth Retardation in Rabbit Femur
| Autor: | Nureddin Ashammakhi, Eero Waris, Timo Waris, Ian T. Jackson, Lee Andrus, Christopher P. Kelly |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Time Factors medicine.medical_treatment Bone fixation Bone Screws Screw placement Absorbable Implants Radiologic Evaluation Animals Medicine Orthopedics and Sports Medicine Femur Growth Plate Bone Development Growth retardation business.industry Epiphysiodesis Right femur General Medicine Leg Length Inequality Surgery Pediatrics Perinatology and Child Health Rabbits Implant business |
| Zdroj: | Journal of Pediatric Orthopaedics. 25:342-345 |
| ISSN: | 0271-6798 |
| DOI: | 10.1097/01.bpo.0000150845.02162.f7 |
| Popis: | A self-reinforced bioabsorbable poly-L-lactide/polyglycolide (SR-PLGA) 80/20 screw 2.0 mm in diameter was implanted transphyseally across the distal growth plate of the right femur in 24 immature rabbits. Radiologic evaluation revealed a mean shortening of 3.1 mm at 3 weeks, 11.1 mm at 6 weeks, 9.3 mm at 24 weeks, 9.0 mm at 48 weeks, and 12.6 mm at 72 weeks compared with the intact contralateral femur. In 13 control rabbits, drilling without screw placement did not cause any statistically significant femoral shortening. Therefore, the transphyseal SR-PLGA 80/20 screw caused growth retardation for 6 weeks postoperatively, after which the normal growth tendency was recovered until the growth plate was closed. The duration of temporary growth retardation correlated with that of strength retention of the SR-PLGA 80/20 copolymer. These findings suggest that SR-PLGA 80/20 screws can be applied in transphyseal bone fixation. The use of bioabsorbable screws for temporary epiphysiodesis seems attractive but requires further study. |
| Databáze: | OpenAIRE |
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