Investigation of MTHFR gene C677T polymorphism in cardiac syndrome X patients
| Autor: | Bülent Demir, Cemre Kandaz, Deniz Özen, Sibel Özyazgan, Burak Önal, A. Gökhan Akkan |
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| Přispěvatelé: | AKKAN, AHMET GÖKHAN, İstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Onal, Burak, AKKAN, Ahmet Gökhan |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Hyperhomocysteinemia Mthfr Clinical Biochemistry 030204 cardiovascular system & hematology Chest pain Gastroenterology C677t 03 medical and health sciences 0302 clinical medicine Polymorphism (computer science) Internal medicine Cardiac syndrome X medicine Humans Immunology and Allergy Genetic Predisposition to Disease 030212 general & internal medicine Endothelial dysfunction Polymorphism Research Articles Methylenetetrahydrofolate Reductase (NADPH2) Microvascular Angina Polymorphism Genetic Kandaz C. ÖNAL B. ÖZEN D. Demir B. AKKAN A. G. ÖZYAZGAN S. -Investigation of MTHFR Gene C677T Polymorphism in Cardiac Syndrome X Patients- Innovation in Drug and Biotechnology 11 - 13 Mayıs 2017 biology business.industry Microvascular Dysfunction Biochemistry (medical) Public Health Environmental and Occupational Health Hematology Middle Aged medicine.disease Pathophysiology digestive system diseases Coronary arteries Cardiac Syndrome X Medical Laboratory Technology medicine.anatomical_structure Case-Control Studies Methylenetetrahydrofolate reductase biology.protein Female medicine.symptom business |
| Popis: | BackgroundDefinition of Cardiac Syndrome X (CSX) refers to groups of patients with positive exercise stress test and normal epicardial coronary arteries on coronary angiography accompanied by chest pain. Although the etiology of CSX is not completely understood, there is a common consensus that its pathophysiology may be associated with endothelial dysfunction resulting in impaired coronary flow. Some polymorphisms observed on the MTHFR gene cause inactivation of the MTHFR enzyme, leading to hyperhomocysteinemia and homocysteinuria, which are prominent risk factors of cardiovascular and cerebrovascular diseases. It was aimed to explain the association of the endothelial dysfunction, which is thought to play a role in the pathophysiology of CSX, with C677T polymorphism on MTHFR gene based on genetic basis. MethodsA total of 176 CSX patients and 196 healthy subjects with similar age and clinical features were compared in terms of C677T polymorphism of the MTHFR gene. Results and ConclusionThere was no significant difference in terms of MTHFR gene C677T polymorphism between CSX patients and controls. When genotypic distribution was compared based on gender in both patients and controls, no significant difference was found between male and female subjects (P>.05). As fasting blood sugar and urea values were significantly higher, alanine aminotransferase and gamma-glutamyl transferase levels were significantly lower in the patients than the controls (P |
| Databáze: | OpenAIRE |
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