Recent Developments in the Treatment of Wet Age-related Macular Degeneration
Autor: | Zois Papadopoulos |
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Rok vydání: | 2020 |
Předmět: |
Vascular Endothelial Growth Factor A
medicine.medical_specialty genetic structures Visual impairment Angiogenesis Inhibitors Retinal Pigment Epithelium Disease Progressive neurodegeneration Biochemistry Macular Degeneration chemistry.chemical_compound Ophthalmology Wet age-related macular degeneration Genetics medicine Humans Ocular disease Retinal pigment epithelium Neovascularization Pathologic business.industry Macular degeneration medicine.disease eye diseases Vascular endothelial growth factor medicine.anatomical_structure chemistry Wet Macular Degeneration sense organs medicine.symptom business Photoreceptor Cells Vertebrate |
Zdroj: | Current Medical Science. 40:851-857 |
ISSN: | 2523-899X 2096-5230 |
DOI: | 10.1007/s11596-020-2253-6 |
Popis: | Age-related macular degeneration (AMD) is the most common cause of irreversible blindness and visual impairment in individuals over the age of 50 years in western societies. More than 25 million people currently suffer from this illness in the world, with an additional 500 000 every year, approximately. It is a multifactorial ocular disease that affects the maculae due to a late-onset progressive neurodegeneration and dysfunction of photoreceptors and retinal pigment epithelium (RPE). There are many subtypes of AMD but basically two broad forms: the nonneovascular (dry, nonexudative) and neovascular (wet, exudative). Exudative AMD is the less common form (about 15%) but tends to progress more rapidly. At the moment, wet AMD is treated primarily on the basis of anti-vascular endothelial growth factor (VEGF) agents, which have led to massive improvement in the prognosis of the disease since they were first introduced. This article focuses on the latest treatment approaches to neovascular AMD. An extensive literature review was performed in order to illustrate the effectiveness of current and future anti-VEGF agents as well as the landmark clinical studies that have been carried out to establish these drugs as a gold standard in the therapy of wet AMD. |
Databáze: | OpenAIRE |
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