Factors Affecting Tumor Ablation during High Intensity Focused Ultrasound Treatment
| Autor: | Do Hyun Park, Sung Koo Lee, Choong Heon Ryu, Jun-Ho Choi, Aizan Hassanuddin, Sang Soo Lee, Dong Wan Seo, Su Hui Kim, Myung-Hwan Kim |
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| Rok vydání: | 2014 |
| Předmět: |
Models
Anatomic medicine.medical_specialty Phantom medicine.medical_treatment Adenocarcinoma Imaging phantom Extracorporeal Tumor ablation Focused ultrasound In vitro model medicine Humans Metal stent Hepatology Cysts Phantoms Imaging business.industry Pancreatic tissue Gastroenterology equipment and supplies High-intensity focused ultrasound Pancreatic Neoplasms Hifu treatment High-Intensity Focused Ultrasound Ablation Original Article Stents Radiology business |
| Zdroj: | Gut and Liver |
| ISSN: | 2005-1212 1976-2283 |
| DOI: | 10.5009/gnl.2014.8.4.433 |
| Popis: | Background/Aims High intensity focused ultrasound (HIFU) utilizes a targeted extracorporeal focused ultrasound beam to ablate neoplastic pancreatic tissue. We used an in vitro model to examine the effects of bone, metallic stents, plastic stents, metal plates, and cyst-like lesions on HIFU treatment. Methods HIFU was delivered to the phantom models implanted with foreign bodies, and the location, shape, and size of the ablated zones were evaluated. Results Bone and metallic plates reflected the ultrasound beam, shifting the ablation zone from the focal zone to the prefocal area. In the phantoms containing metal stent, plastic stent, and cyst, most of the ablative energy was reflected to the prefocal area by the surface, with the remainder penetrating through the phantom. The area of the ablated margins was significantly larger in size and volume than the intended focal ablation zone. Conclusions During HIFU therapy, artificial or anatomical barriers could affect the direction of the ultrasound beams, shifting the ablation zone from the focal area to a prefocal site with a larger than expected ablation zone. These factors should be considered prior to HIFU treatment for pancreatic tumors because they could limit ablation success, in addition to causing complications. |
| Databáze: | OpenAIRE |
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