Asthma and gastro-Oesophageal reflux: can the response to anti-reflux therapy be predicted?
| Autor: | K. Liippo, T. Kiljander, Erkki O. Terho, E.-R. Salomaa, E. Hietanen, Hans Helenius |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty medicine.drug_class Proton-pump inhibitor Placebo Severity of Illness Index Gastroenterology Body Mass Index Double-Blind Method Internal medicine Confidence Intervals Odds Ratio medicine Humans Omeprazole Aged Asthma Cross-Over Studies Esophageal disease business.industry Reflux gastro-oesophageal reflux Hydrogen-Ion Concentration Middle Aged Anti-Ulcer Agents medicine.disease Surgery Logistic Models Treatment Outcome Multivariate Analysis Gastroesophageal Reflux Population study Female business Body mass index omeprazole medicine.drug |
| Zdroj: | Respiratory Medicine. 95:387-392 |
| ISSN: | 0954-6111 |
| Popis: | The aim of the study was to investigate which features predict favourable response to omeprazole therapy in asthmatics with gastro-oesophageal reflux (GER). The study population consisted of 52 outpatient asthmatics with GER who had completed an intervention where they were randomized to receive omeprazole 40 mg once a day or placebo for 8 weeks. After a 2-week washout period the patients were crossed over. Asthma symptoms were found to be relievedor = 20% in 18 (35%) patients who were thus regarded as responders. A logistic regression analysis was performed in order to identify which features separate the responders from the non-responders. More responders were found among the patients whose body mass index (BMI) was higher (P = 0.02) or whose distal esophageal reflux was more severe [total time (%) pH4 (P = 0.01) or time (%) pH4 in upright position (P = 0.04)]. Adding other predictors to the total time (%) pH4, which was the most significant predictor for response in multi-variate analysis, did not further increase the prediction for favourable outcome. It is concluded that severe distal oesophageal reflux and obesity predict amelioration in asthma symptoms after 8-week omeprazole treatment in asthmatics with GER. Adding more than one predictor does not seem to further increase prediction for favourable asthma response. |
| Databáze: | OpenAIRE |
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