Behavioural fever is a synergic signal amplifying the innate immune response
| Autor: | Reynaldo Vargas, Amparo Estepa, Mario Huerta, Frederick W. Goetz, Sonia Rey, Simon MacKenzie, Janice Moore, Nerea Roher, Pablo Garcia-Valtanen, Felicity A. Huntingford, Sebastian Boltana |
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| Přispěvatelé: | Boltana, Sebastian, Rey, Sonia, Roher, Nerea, Vargas, Reynaldo, Huerta, Mario, Huntingford, Felicity Anne, Goetz, Frederick William, Moore, Janice, Garcia-Valtanen, Pablo, Estepa, Amparo, Mackenzie, S |
| Předmět: |
anti-viral response
Behavioural fever General Biochemistry Genetics and Molecular Biology Transcriptome Immune system Animals RNA Messenger Gene–environment interaction behavioural fever gene–environment interaction Zebrafish Pathogen Research Articles General Environmental Science Innate immune system General Immunology and Microbiology biology Behavior Animal Temperature Brain General Medicine Zebrafish Proteins biology.organism_classification Immunity Innate Gene-environment interaction Up-Regulation Ectotherm Anti-viral response Immunology Signal transduction General Agricultural and Biological Sciences Signal Transduction |
| Zdroj: | Scopus-Elsevier Recercat: Dipósit de la Recerca de Catalunya Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) Recercat. Dipósit de la Recerca de Catalunya instname Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Proceedings of the Royal Society B: Biological Sciences |
| ISSN: | 0962-8452 |
| Popis: | Behavioural fever, defined as an acute change in thermal preference driven by pathogen recognition, has been reported in a variety of invertebrates and ectothermic vertebrates. It has been suggested, but so far not confirmed, that such changes in thermal regime favour the immune response and thus promote survival. Here, we show that zebrafish display behavioural fever that acts to promote extensive and highly specific temperature-dependent changes in the brain transcriptome. The observed coupling of the immune response to fever acts at the gene–environment level to promote a robust, highly specific time-dependent anti-viral response that, under viral infection, increases survival. Fish that are not offered a choice of temperatures and that therefore cannot express behavioural fever show decreased survival under viral challenge. This phenomenon provides an underlying explanation for the varied functional responses observed during systemic fever. Given the effects of behavioural fever on survival and the fact that it exists across considerable phylogenetic space, such immunity–environment interactions are likely to be under strong positive selection. Refereed/Peer-reviewed |
| Databáze: | OpenAIRE |
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