Angiotensin II and norepinephrine antagonize the secretory effect of VIP in rat ileum and colon
| Autor: | Thomas M. O'Dorisio, M. Bhaskar Rao, Jack M. George, Samuel Cataland, T.S. Gaginella |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Male
medicine.medical_specialty Colon Physiology medicine.medical_treatment Vasoactive intestinal peptide Ileum Biochemistry Norepinephrine (medication) Norepinephrine Cellular and Molecular Neuroscience Endocrinology In vivo Internal medicine medicine Animals Secretion Intestinal Mucosa Saline Chemistry Angiotensin II Rats Inbred Strains Small intestine Rats Kinetics medicine.anatomical_structure hormones hormone substitutes and hormone antagonists Vasoactive Intestinal Peptide medicine.drug |
| Zdroj: | Peptides. 5:291-294 |
| ISSN: | 0196-9781 |
| DOI: | 10.1016/0196-9781(84)90221-3 |
| Popis: | Vasoactive intestinal polypeptide (VIP) induces intestinal secretion of water and electrolytes in experimental animals and man. We assessed the ability of angiotensin II (AII) and norepinephrine (NE) to block the secretion evoked by VIP, in vivo. Ileal and colonic segments in rats were perfused in situ for two hours with a physiological buffer containing [14C]-PEG-4000 as a volume marker. Saline (0.9% NaCl) was infused intravenously during the first hour and VIP or a combination of VIP plus AII or NE was infused during the second hour. All (0.7 ng/kg/min) alone enhanced water absorption significantly (p less than 0.01) in the ileum and an appreciable, although not a statistically significant, effect was observed in the colon. AII antagonized the secretory effects of VIP in the ileum as well as in the colon. Norepinephrine (5 micrograms/kg/min) also reversed the effect of VIP on the small intestine and colon. Although the mechanism by which AII antagonizes the secretory effects of VIP has not been identified, it is probable that AII promotes absorption, at least in part secondary to release of mucosal NE. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|