6-(Substituted methylene)penems, potent broad spectrum inhibitors of bacterial .BETA.-lactamase. I. Racemic 6-ethylidenepenems
| Autor: | Neal Frederick Osborne, Michael J. Basker |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Magnetic Resonance Spectroscopy
Chemical Phenomena Stereochemistry medicine.drug_class Antibiotics beta-Lactams chemistry.chemical_compound Broad spectrum Beta-Lactamase I Drug Discovery polycyclic compounds medicine Cephaloridine Methylene Pharmacology biology Drug interaction biology.organism_classification Anti-Bacterial Agents Chemistry chemistry Enzyme inhibitor biology.protein beta-Lactamase Inhibitors Bacteria medicine.drug |
| Zdroj: | The Journal of Antibiotics. 43:70-75 |
| ISSN: | 1881-1469 0021-8820 |
| Popis: | The dehydration of various 6-(1-hydroxyethyl)penems to give E- and Z-6-ethylidenepenems is described. Both isomers have been shown to be potent broad spectrum inhibitors of bacterial beta-lactamases capable of reducing the MIC values of beta-lactam antibiotics such as amoxycillin and cephaloridine against a wide range of resistant organisms. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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