B-cell development and pneumococcal immunity in vertically acquired HIV infection
| Autor: | Richard Gilson, Hannah Poulsom, David Goldblatt, Clare Hayden, Nigel Klein, Helen Baxendale, E Jungmann, Sarah Eisen, C Young, Marianne C. Jacobsen |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male Adolescent Immunology B-Lymphocyte Subsets HIV Infections medicine.disease_cause Immunoglobulin G Pneumococcal Infections Pneumococcal Vaccines 03 medical and health sciences Young Adult 0302 clinical medicine Phagocytosis Immunity Streptococcus pneumoniae medicine Disease Transmission Infectious Immunology and Allergy Humans 030212 general & internal medicine Young adult Child biology business.industry Opsonin Proteins medicine.disease Flow Cytometry Antibodies Bacterial Infectious Disease Transmission Vertical Immunity Humoral Pneumococcal infections 030104 developmental biology Infectious Diseases Immunization Immunoglobulin M Humoral immunity biology.protein Female Antibody business |
| Zdroj: | AIDS (London, England). 30(12) |
| ISSN: | 1473-5571 |
| Popis: | Objectives Many children with HIV infection now survive into adulthood. This study explored the impact of vertically acquired HIV in the era of antiretroviral therapy on the development of humoral immunity. Design Natural and vaccine-related immunity to pneumococcus and B-cell phenotype was characterized and compared in three groups of young adults: those with vertically-acquired infection, those with horizontally acquired infection and healthy controls. Methods Serotype-specific pneumococcal (Pnc) immunoglobulin M and G concentrations before and up to 1 year post-Pnc polysaccharide (Pneumovax) immunization were determined, and opsonophagocytic activity was analysed. B-cell subpopulations and dynamic markers of B-cell signalling, turnover and susceptibility to apoptosis were evaluated by flow cytometry. Results HIV-infected patients showed impaired natural Pnc immunity and reduced humoral responses to immunization with Pneumovax; this was greatest in those viraemic at time of the study. Early-life viral control before the age of 10 years diminished these changes. Expanded populations of abnormally activated and immature B-cells were seen in both HIV-infected cohorts. Vertically infected patients were particularly vulnerable to reductions in marginal zone and switched memory populations. These aberrations were reduced in patients with early-life viral control. Conclusion In children with HIV, damage to B-cell memory populations and impaired natural and vaccine immunity to pneumococcus is evident in early adult life. Sustained viral control from early childhood may help to limit this effect and optimize humoral immunity in adult life. |
| Databáze: | OpenAIRE |
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