Amide chemical exchange saturation transfer at 7 T: a possible biomarker for detecting early response to neoadjuvant chemotherapy in breast cancer patients

Autor: Moritz Zaiss, Rajni A. Jibodh, Dennis W.J. Klomp, Vitaliy Khlebnikov, Jannie P. Wijnen, Erwin Krikken, Paul J. van Diest, Peter R. Luijten, Hanneke W. M. van Laarhoven
Přispěvatelé: CCA - Imaging and biomarkers, Oncology, AGEM - Re-generation and cancer of the digestive system
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Oncology
Adult
Cancer Research
medicine.medical_specialty
medicine.medical_treatment
Contrast Media
Breast Neoplasms
7T MRI
lcsh:RC254-282
APT CEST
Biomarkers
Pharmacological
Statistics
Nonparametric
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Breast cancer
Surgical oncology
Internal medicine
Response prediction
medicine
Biomarkers
Tumor
NAC treatment
Humans
7 T MRI
Breast
Stage (cooking)
Neoplasm Staging
Chemotherapy
medicine.diagnostic_test
business.industry
Chemical exchange
Magnetic resonance imaging
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Amides
Magnetic Resonance Imaging
Neoadjuvant Therapy
Saturation transfer
030220 oncology & carcinogenesis
Biomarker (medicine)
Female
Protons
business
Research Article
Zdroj: Breast Cancer Research : BCR
Breast Cancer Research
Breast Cancer Research, Vol 20, Iss 1, Pp 1-9 (2018)
Breast Cancer Research, 20(1). BioMed Central
Breast cancer research, 20(1):51. BioMed Central
ISSN: 1465-542X
1465-5411
Popis: Background The purpose of this work was to investigate noninvasive early detection of treatment response of breast cancer patients to neoadjuvant chemotherapy (NAC) using chemical exchange saturation transfer (CEST) measurements sensitive to amide proton transfer (APT) at 7 T. Methods CEST images were acquired in 10 tumors of nine breast cancer patients treated with NAC. APT signals in the tumor, before and after the first cycle of NAC, were quantified using a three-pool Lorentzian fit of the z-spectra in the region of interest. The changes in APT were subsequently related to pathological response after surgery defined by the Miller-Payne system. Results Significant differences (P 0.05, Kruskal-Wallis test). Conclusions This preliminary study shows the feasibility of using APT CEST magnetic resonance imaging as a noninvasive biomarker to assess the effect of NAC in an early stage of NAC treatment of breast cancer patients. Trial registration Registration number, NL49333.041.14/NTR4980. Registered on 16 October 2014.
Databáze: OpenAIRE
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