Synthesis, Characterization, DNA Binding, Light Switch 'On and Off', Docking Studies and Cytotoxicity, of Ruthenium(II) and Cobalt(III) Polypyridyl Complexes
| Autor: | A. Srishailam, Yata Praveen Kumar, M. Rajender Reddy, Putta Venkat Reddy, Navaneetha Nambigari, Sirasani Satyanarayana |
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| Rok vydání: | 2014 |
| Předmět: |
Magnetic Resonance Spectroscopy
Light Spectrophotometry Infrared Sociology and Political Science Molecular model Cell Survival Pyridines Light switch Stereochemistry Phenanthroline Clinical Biochemistry Intercalation (chemistry) chemistry.chemical_element Biochemistry Ruthenium chemistry.chemical_compound Neoplasms Organometallic Compounds Tumor Cells Cultured Spectroscopy Bacteria Cobalt DNA Carbon-13 NMR Intercalating Agents Anti-Bacterial Agents Clinical Psychology Crystallography chemistry Proton NMR Spectrophotometry Ultraviolet Cyclic voltammetry Law Social Sciences (miscellaneous) Phenanthrolines |
| Zdroj: | Journal of Fluorescence. 24:803-817 |
| ISSN: | 1573-4994 1053-0509 |
| Popis: | The novel ligand (dmbip) 2-(4-N, N-dimethylbenzenamine)1H-imidazo[4, 5-f][1, 10]phenanthroline and its complexes [Ru(phen)2dmbip](2+) (1), [Ru(bpy)2dmbip](2+) (2), [Co(phen)2dmbip](3+) (3) and [Co(bpy)2dmbip](3+) (4) [where phen = 1, 10-phenanthroline, bpy = 2, 2'-bipyridine], have been synthesized and characterized by elemental analysis, IR, UV-Vis, (1)H NMR, (13)C NMR and Mass spectra. The DNA binding properties of the complexes were investigated by absorption, emission, quenching studies, light switch "on and off", salt dependent, sensor (cation and anion) studies, viscosity measurements, cyclic voltammetry, molecular modeling and docking studies. The four complexes were screened for Photo cleavage of pBR322 DNA, antimicrobial activity and cytotoxicity. The experimental results indicate that the four complexes can intercalate into DNA base pairs. The DNA-binding affinities of these complexes follow the order [Ru(phen)2dmbip](2+)[Co(phen)2dmbip](3+)[Ru(bpy)2dmbip](2+)[Co(bpy)2dmbip](3+). |
| Databáze: | OpenAIRE |
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