Multi-modal MRI of mild traumatic brain injury
| Autor: | Xintian Yu, James J. McCarthy, Ponnada A. Narayana, Harvey S. Levin, Emmy R Miller, Jill V. Hunter, Elisabeth A. Wilde, Claudia S. Robertson, Khader M. Hasan, Vipulkumar S. Patel |
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| Rok vydání: | 2015 |
| Předmět: |
Male
acr anterior region of corona radiata Internal capsule lcsh:RC346-429 Magnetic resonance spectroscopic imaging Nuclear magnetic resonance ec external capsule alic anterior limb of internal capsule Orthopedic injury Magnetization transfer ratio pcr posterior region of corona radiata biology medicine.diagnostic_test Superior longitudinal fasciculus cs centrum semiovale pcg paracingulate gyrus Regular Article Middle Aged mfg superior frontal gyrus Diffusion tensor imaging medicine.anatomical_structure Neurology ilf inferior longitudinal fasciculus sfg superior frontal gyrus lcsh:R858-859.7 Female Psychology plic posterior limb of internal capsule scr superior region of corona radiata sfo superior fronto-occipital fasciculus Adult jlc juxtapositional lobule cortex ic internal capsule Cognitive Neuroscience lcsh:Computer applications to medicine. Medical informatics White matter cg cingulate gyrus Young Adult Magnetic resonance imaging Image Interpretation Computer-Assisted Fasciculus medicine Humans Radiology Nuclear Medicine and imaging Inferior longitudinal fasciculus cst corticospinal tract Mild traumatic brain injury Brain Concussion lcsh:Neurology. Diseases of the nervous system business.industry biology.organism_classification cc corpus callosum Tensor based morphometry ifo inferior fronto-occipital fasciculus Neurology (clinical) slf superior longitudinal fasciculus Nuclear medicine business Diffusion MRI |
| Zdroj: | NeuroImage: Clinical, Vol 7, Iss C, Pp 87-97 (2015) NeuroImage : Clinical |
| ISSN: | 2213-1582 |
| DOI: | 10.1016/j.nicl.2014.07.010 |
| Popis: | Multi-modal magnetic resonance imaging (MRI) that included high resolution structural imaging, diffusion tensor imaging (DTI), magnetization transfer ratio (MTR) imaging, and magnetic resonance spectroscopic imaging (MRSI) were performed in mild traumatic brain injury (mTBI) patients with negative computed tomographic scans and in an orthopedic-injured (OI) group without concomitant injury to the brain. The OI group served as a comparison group for mTBI. MRI scans were performed both in the acute phase of injury (~24 h) and at follow-up (~90 days). DTI data was analyzed using tract based spatial statistics (TBSS). Global and regional atrophies were calculated using tensor-based morphometry (TBM). MTR values were calculated using the standard method. MRSI was analyzed using LC Model. At the initial scan, the mean diffusivity (MD) was significantly higher in the mTBI cohort relative to the comparison group in several white matter (WM) regions that included internal capsule, external capsule, superior corona radiata, anterior corona radiata, posterior corona radiata, inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, forceps major and forceps minor of the corpus callosum, superior longitudinal fasciculus, and corticospinal tract in the right hemisphere. TBSS analysis failed to detect significant differences in any DTI measures between the initial and follow-up scans either in the mTBI or OI group. No significant differences were found in MRSI, MTR or morphometry between the mTBI and OI cohorts either at the initial or follow-up scans with or without family wise error (FWE) correction. Our study suggests that a number of WM tracts are affected in mTBI in the acute phase of injury and that these changes disappear by 90 days. This study also suggests that none of the MRI-modalities used in this study, with the exception of DTI, is sensitive in detecting changes in the acute phase of mTBI. |
| Databáze: | OpenAIRE |
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