Unilateral Dampening of Bmp Activity by Nodal Generates Cardiac Left-Right Asymmetry
| Autor: | Florian Priller, Franziska Rudolph, Justus Veerkamp, Cécile Otten, Zoltán Cseresnyés, Salim Abdelilah-Seyfried, Liliana Schaefer, Marc Renz |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Nodal Protein Left-Right Determination Factors Morphogenesis Motility Nodal signaling Biology General Biochemistry Genetics and Molecular Biology Extracellular matrix Cell Movement Internal medicine medicine Animals Glucuronosyltransferase Molecular Biology Zebrafish Body Patterning Nonmuscle Myosin Type IIB Heart development Nonmuscle Myosin Type IIA Gene Expression Regulation Developmental Heart Cell Biology Zebrafish Proteins Cell biology Endocrinology Bone Morphogenetic Proteins Signal transduction NODAL Hyaluronan Synthases Signal Transduction Developmental Biology |
| Zdroj: | Developmental Cell. 24:660-667 |
| ISSN: | 1534-5807 |
| DOI: | 10.1016/j.devcel.2013.01.026 |
| Popis: | SummarySignaling by Nodal and Bmp is essential for cardiac laterality. How activities of these pathways translate into left-right asymmetric organ morphogenesis is largely unknown. We show that, in zebrafish, Nodal locally reduces Bmp activity on the left side of the cardiac field. This effect is mediated by the extracellular matrix enzyme Hyaluronan synthase 2, expression of which is induced by Nodal. Unilateral reduction of Bmp signaling results in lower expression of nonmuscle myosin II and higher cell motility on the left, driving asymmetric displacement of the entire cardiac field. In silico modeling shows that left-right differences in cell motility are sufficient to induce a robust, directional migration of cardiac tissue. Thus, the mechanism underlying the formation of cardiac left-right asymmetry involves Nodal modulating an antimotogenic Bmp activity. |
| Databáze: | OpenAIRE |
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