Anticancer and antibacterial potentials induced post short-term exposure to electromagnetic field and silver nanoparticles and related pathological and genetic alterations: in vitro study

Autor: Aly Fahmy Mohamed, Mohamed Nasr, Mohamed E. Amer, Tamer M. M. Abuamara, Wagih M. Abd-Elhay, Hassan Fathy Kaabo, Emad Eldin R. Matar, Laila E. El Moselhy, Tamer Albasyoni Gomah, Mohammed Abd EL-Fatah Deban, Rania Ibrahim Shebl
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Infectious Agents and Cancer
Infectious Agents and Cancer, Vol 17, Iss 1, Pp 1-16 (2022)
ISSN: 1750-9378
Popis: Background Resistance to antibiotics and anticancer therapy is a serious global health threat particularly in immunosuppressed cancer patients. Current study aimed to estimate the antibacterial and anticancer potentials of short-term exposure to extremely low frequency electromagnetic field (ELF-EMF) and silver nanoparticles (AgNPs) either in sole or combined form. Methods Antibacterial activity was evaluated via determination of the bacterial viable count reduction percentage following exposure, whereas their ability to induce apoptosis in breast cancer (MCF-7) cell line was detected using annexin V-fluorescein isothiocyanate and cell cycle analysis. Also, oxidative stress potential and molecular profile were investigated. Results ELF-EMF and AgNPs significantly (p K. pneumonia viable count of compared to that of S. aureus in a time dependent manner till reaching 100% inhibition when ELF-EMF was applied in combination to 10 µM/ml AgNPs for 2 h. Apoptosis induction was obvious following exposure to either ELF-EMF or AgNPs, however their apoptotic potential was intensified when applied in combination recording significantly (p Conclusions The antibacterial and anticancer potentials of these agents might be related to their ability to induce oxidative stress, suggesting their potentials as novel candidates for controlling infections and triggering cancer cells towards self-destruction.
Databáze: OpenAIRE
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