Antigen-specific, MHC nonrestricted T helper cell-induced B cell activation
| Autor: | Steven M. Friedman, Elliot K. Chartash, Mary K. Crow, Juan Angel Jover |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Immunology
B-cell receptor Naive B cell Receptors Antigen T-Cell chemical and pharmacologic phenomena Biology Lymphocyte Activation Major histocompatibility complex Cell Line Cell–cell interaction Antigen medicine Humans Immunology and Allergy B cell B-Lymphocytes HLA-D Antigens Articles HLA-DR Antigens T-Lymphocytes Helper-Inducer T helper cell MHC restriction Cell biology Antigens Differentiation B-Lymphocyte medicine.anatomical_structure Trinitrobenzenes Antigens Surface biology.protein |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| DOI: | 10.1084/jem.164.5.1773 |
| Popis: | We used a cloned, TNP-specific, MHC-restricted, human Th cell line, E-11, and an assay of cognate Th-B cell interaction, BLAST-2 antigen expression on the B cell surface, to investigate the functional nature of the Th cell antigen receptor. We observed that E-11 induces BLAST-2 expression by resting B cells in a hapten-dependent, hapten-specific, but MHC nonrestricted manner. The implication of these results for the Th cell receptor are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|