Effect of quetiapine in psychotic Parkinson's disease patients: a double-blind labeled study of 3 months' duration
| Autor: | Eugenia Dobronevsky, Ala Miniovitz, Colin Klein, Tatiana Prokhorov, Jose Martin Rabey |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Dibenzothiazepines medicine.drug_class medicine.medical_treatment Atypical antipsychotic Pimavanserin Placebo Severity of Illness Index chemistry.chemical_compound Quetiapine Fumarate Double-Blind Method Internal medicine Brief Psychiatric Rating Scale Outcome Assessment Health Care medicine Humans Antipsychotic Psychiatry Aged Aged 80 and over Hamilton Rating Scale for Depression Parkinson Disease Neurology chemistry Psychotic Disorders Clinical Global Impression Quetiapine Female Neurology (clinical) Psychology medicine.drug Antipsychotic Agents Follow-Up Studies |
| Zdroj: | Movement disorders : official journal of the Movement Disorder Society. 22(3) |
| ISSN: | 0885-3185 |
| Popis: | This double-blind randomized study examined the effect of quetiapine (QTP) on drug-induced psychosis (DIP) in Parkinson's disease (PD). Conventional antipsychotic drugs are associated with adverse extrapyramidal effects. QTP is a new atypical antipsychotic drug used in the treatment of psychosis in PD. A total of 58 consecutive psychotic PD patients (mean age, 75 ± 8.3 years; mean disease duration, 10.5 ± 6.4 years; 29 with dementia) were randomly assigned to 2 groups: 30 were treated with QTP (mean dose, 119.2 ± 56.4 mg) and 28 received placebo for 3 months. The motor part of the Unified Parkinson's Disease Rating Scale, the Brief Psychiatric Rating Scale, the Mini-Mental State Examination, the Hamilton Rating Scale for Depression, the Epworth Sleepiness Score, and the Clinical Global Impression Scale were administered before and during the study. No significant difference was found between the groups in all parameters. There were 32 PD patients (55%) completed the 3-month study (15 [26%] QTP and 17 [29%] placebo). Treatment was interrupted in 15 patients in the QTP and 11 in the placebo groups. This double-blind study did not show a beneficial effect of QTP for the treatment of DIP in PD. The high rate of withdrawal probably influenced the results. Larger double-blind studies are required. © 2006 Movement Disorder Society |
| Databáze: | OpenAIRE |
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